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Protein kinase C alpha

Name And Classification

ID:  ALA299

Type:  SINGLE PROTEIN

Synonyms:   2.7.11.13 | PKC-A | PKC-alpha | PKCA | PRKACA | PRKCA | Protein kinase C alpha type

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Enzyme / Kinase / Protein Kinase / AGC protein kinase group / AGC protein kinase PKC family / AGC protein kinase PKC alpha subfamily

Target Relations

ALA IDRelationshipPref NameTarget Type
ALA2093867SUBSET OFProtein kinase C (PKC)PROTEIN FAMILY
ALA3137267SUBSET OFPKC alpha and beta-2PROTEIN FAMILY
ALA2096620SUBSET OFProtein kinase C, PKC; classical/novelPROTEIN FAMILY

Target Components

DescriptionRelationshipAccession
Protein kinase C alpha typePROTEINP17252

Associated Active Ligands

  1. Tetrahydrouridine
    ALA6291

    Name:
    2-(3-{3-[4-(1-Methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-indol-1-yl}-propyl)-isothiourea

    Mol. Formula:
    C25H23N5O2S

    M.W.:
    457.56

    Type:
    Small molecule

    AlogP:
    3.72

    Polar Surface Area:
    105.90

    HBA:
    6

    HBD:
    3

    #RO5 Violations:
    0

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.18

    DETAILS
  2. Tetrahydrouridine
    ALA6644

    Name:
    (2S,5S)-5-Hydroxymethyl-2-isopropyl-7-methoxy-1-methyl-1,4,5,6-tetrahydro-2H-benzo[e][1,4]diazocin-3-one

    Mol. Formula:
    C16H24N2O3

    M.W.:
    292.38

    Type:
    Small molecule

    AlogP:
    1.19

    Polar Surface Area:
    61.80

    HBA:
    4

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.88

    DETAILS
  3. Tetrahydrouridine
    ALA7078

    Name:
    (2S,5S)-8-Dec-1-ynyl-5-hydroxymethyl-2-isopropyl-7-methoxy-1-methyl-1,4,5,6-tetrahydro-2H-benzo[e][1,4]diazocin-3-one

    Mol. Formula:
    C26H40N2O3

    M.W.:
    428.62

    Type:
    Small molecule

    AlogP:
    4.29

    Polar Surface Area:
    61.80

    HBA:
    4

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    9

    Passes Ro3:
    N

    QED Weighted:
    0.45

    DETAILS
  4. Tetrahydrouridine
    ALA267144

    Name:
    (2S,5S)-5-Hydroxymethyl-2-isopropyl-1-methyl-1,4,5,6-tetrahydro-2H-benzo[e][1,4]diazocin-3-one

    Mol. Formula:
    C15H22N2O2

    M.W.:
    262.35

    Type:
    Small molecule

    AlogP:
    1.18

    Polar Surface Area:
    52.57

    HBA:
    3

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    Y

    QED Weighted:
    0.84

    DETAILS
  5. Tetrahydrouridine
    ALA6453

    Name:
    (2S,5S)-8-Dec-1-ynyl-5-hydroxymethyl-2-isopropyl-1-methyl-1,4,5,6-tetrahydro-2H-benzo[e][1,4]diazocin-3-one

    Mol. Formula:
    C25H38N2O2

    M.W.:
    398.59

    Type:
    Small molecule

    AlogP:
    4.28

    Polar Surface Area:
    52.57

    HBA:
    3

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    8

    Passes Ro3:
    N

    QED Weighted:
    0.51

    DETAILS
  6. Tetrahydrouridine
    ALA8659

    Name:
    (Z)-Octadec-9-enoic acid

    Mol. Formula:
    C18H34O2

    M.W.:
    282.47

    Type:
    Small molecule

    AlogP:
    6.11

    Polar Surface Area:
    37.30

    HBA:
    1

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    15

    Passes Ro3:
    N

    QED Weighted:
    0.29

    DETAILS
  7. Tetrahydrouridine
    ALA285801

    Name:
    (10S,13S)-13-Hydroxymethyl-10-isopropyl-9-methyl-5-octyl-3,9,12-triaza-tricyclo[6.6.1.0*4,15*]pentadeca-1,4,6,8(15)-tetraen-11-one

    Mol. Formula:
    C25H39N3O2

    M.W.:
    413.61

    Type:
    Small molecule

    AlogP:
    4.56

    Polar Surface Area:
    68.36

    HBA:
    3

    HBD:
    3

    #RO5 Violations:
    0

    #Rotatable Bonds:
    9

    Passes Ro3:
    N

    QED Weighted:
    0.53

    DETAILS
  8. Tetrahydrouridine
    ALA28205

    Name:
    (2S,5S)-8-Decyl-5-hydroxymethyl-2-isopropyl-1-methyl-1,4,5,6-tetrahydro-2H-benzo[e][1,4]diazocin-3-one

    Mol. Formula:
    C25H42N2O2

    M.W.:
    402.62

    Type:
    Small molecule

    AlogP:
    4.86

    Polar Surface Area:
    52.57

    HBA:
    3

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    11

    Passes Ro3:
    N

    QED Weighted:
    0.52

    DETAILS
  9. Tetrahydrouridine
    ALA282159

    Name:
    (1S,3R,4S,9R,13S,14R)-13-Hydroxy-9-((R)-1-hydroxy-ethyl)-3-[(1S,4S)-4-(3-hydroxy-phenyl)-4-methoxy-1-methyl-butyl]-4,14,16,16-tetramethyl-2,6,10,17-tetraoxa-tricyclo[11.3.1.1*1,5*]octadecane-7,11-dione

    Mol. Formula:
    C32H48O10

    M.W.:
    592.73

    Type:
    Small molecule

    AlogP:
    4.39

    Polar Surface Area:
    140.98

    HBA:
    10

    HBD:
    3

    #RO5 Violations:
    1

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.39

    DETAILS
  10. Tetrahydrouridine
    ALA26811

    Name:
    (5R,6S)-9-Dodec-(E)-ylidene-6-hydroxymethyl-1,7-dioxa-spiro[4.4]nonane-2,8-dione

    Mol. Formula:
    C20H32O5

    M.W.:
    352.47

    Type:
    Small molecule

    AlogP:
    3.83

    Polar Surface Area:
    72.83

    HBA:
    5

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    11

    Passes Ro3:
    N

    QED Weighted:
    0.35

    DETAILS