ID: ALA299
Type: SINGLE PROTEIN
Synonyms: 2.7.11.13 | PKC-A | PKC-alpha | PKCA | PRKACA | PRKCA | Protein kinase C alpha type
Organism: Homo sapiens
Species Group: Homo sapiens
Protein Target Classification: Enzyme / Kinase / Protein Kinase / AGC protein kinase group / AGC protein kinase PKC family / AGC protein kinase PKC alpha subfamily
ALA ID | Relationship | Pref Name | Target Type |
---|---|---|---|
ALA2093867 | SUBSET OF | Protein kinase C (PKC) | PROTEIN FAMILY |
ALA3137267 | SUBSET OF | PKC alpha and beta-2 | PROTEIN FAMILY |
ALA2096620 | SUBSET OF | Protein kinase C, PKC; classical/novel | PROTEIN FAMILY |
Description | Relationship | Accession |
---|---|---|
Protein kinase C alpha type | PROTEIN | P17252 |
Name:
2-(3-{3-[4-(1-Methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-indol-1-yl}-propyl)-isothiourea
Mol. Formula:
C25H23N5O2S
M.W.:
457.56
Type:
Small molecule
AlogP:
3.72
Polar Surface Area:
105.90
HBA:
6
HBD:
3
#RO5 Violations:
0
#Rotatable Bonds:
6
Passes Ro3:
N
QED Weighted:
0.18
Name:
(2S,5S)-5-Hydroxymethyl-2-isopropyl-7-methoxy-1-methyl-1,4,5,6-tetrahydro-2H-benzo[e][1,4]diazocin-3-one
Mol. Formula:
C16H24N2O3
M.W.:
292.38
Type:
Small molecule
AlogP:
1.19
Polar Surface Area:
61.80
HBA:
4
HBD:
2
#RO5 Violations:
0
#Rotatable Bonds:
3
Passes Ro3:
N
QED Weighted:
0.88
Name:
(2S,5S)-8-Dec-1-ynyl-5-hydroxymethyl-2-isopropyl-7-methoxy-1-methyl-1,4,5,6-tetrahydro-2H-benzo[e][1,4]diazocin-3-one
Mol. Formula:
C26H40N2O3
M.W.:
428.62
Type:
Small molecule
AlogP:
4.29
Polar Surface Area:
61.80
HBA:
4
HBD:
2
#RO5 Violations:
0
#Rotatable Bonds:
9
Passes Ro3:
N
QED Weighted:
0.45
Name:
(2S,5S)-5-Hydroxymethyl-2-isopropyl-1-methyl-1,4,5,6-tetrahydro-2H-benzo[e][1,4]diazocin-3-one
Mol. Formula:
C15H22N2O2
M.W.:
262.35
Type:
Small molecule
AlogP:
1.18
Polar Surface Area:
52.57
HBA:
3
HBD:
2
#RO5 Violations:
0
#Rotatable Bonds:
2
Passes Ro3:
Y
QED Weighted:
0.84
Name:
(2S,5S)-8-Dec-1-ynyl-5-hydroxymethyl-2-isopropyl-1-methyl-1,4,5,6-tetrahydro-2H-benzo[e][1,4]diazocin-3-one
Mol. Formula:
C25H38N2O2
M.W.:
398.59
Type:
Small molecule
AlogP:
4.28
Polar Surface Area:
52.57
HBA:
3
HBD:
2
#RO5 Violations:
0
#Rotatable Bonds:
8
Passes Ro3:
N
QED Weighted:
0.51
Name:
(10S,13S)-13-Hydroxymethyl-10-isopropyl-9-methyl-5-octyl-3,9,12-triaza-tricyclo[6.6.1.0*4,15*]pentadeca-1,4,6,8(15)-tetraen-11-one
Mol. Formula:
C25H39N3O2
M.W.:
413.61
Type:
Small molecule
AlogP:
4.56
Polar Surface Area:
68.36
HBA:
3
HBD:
3
#RO5 Violations:
0
#Rotatable Bonds:
9
Passes Ro3:
N
QED Weighted:
0.53
Name:
(2S,5S)-8-Decyl-5-hydroxymethyl-2-isopropyl-1-methyl-1,4,5,6-tetrahydro-2H-benzo[e][1,4]diazocin-3-one
Mol. Formula:
C25H42N2O2
M.W.:
402.62
Type:
Small molecule
AlogP:
4.86
Polar Surface Area:
52.57
HBA:
3
HBD:
2
#RO5 Violations:
0
#Rotatable Bonds:
11
Passes Ro3:
N
QED Weighted:
0.52
Name:
(1S,3R,4S,9R,13S,14R)-13-Hydroxy-9-((R)-1-hydroxy-ethyl)-3-[(1S,4S)-4-(3-hydroxy-phenyl)-4-methoxy-1-methyl-butyl]-4,14,16,16-tetramethyl-2,6,10,17-tetraoxa-tricyclo[11.3.1.1*1,5*]octadecane-7,11-dione
Mol. Formula:
C32H48O10
M.W.:
592.73
Type:
Small molecule
AlogP:
4.39
Polar Surface Area:
140.98
HBA:
10
HBD:
3
#RO5 Violations:
1
#Rotatable Bonds:
7
Passes Ro3:
N
QED Weighted:
0.39
Name:
(5R,6S)-9-Dodec-(E)-ylidene-6-hydroxymethyl-1,7-dioxa-spiro[4.4]nonane-2,8-dione
Mol. Formula:
C20H32O5
M.W.:
352.47
Type:
Small molecule
AlogP:
3.83
Polar Surface Area:
72.83
HBA:
5
HBD:
1
#RO5 Violations:
0
#Rotatable Bonds:
11
Passes Ro3:
N
QED Weighted:
0.35