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Rho-associated protein kinase 1

Name And Classification

ID:  ALA3231

Type:  SINGLE PROTEIN

Synonyms:   2.7.11.1 | p160 ROCK-1 | p160ROCK | Renal carcinoma antigen NY-REN-35 | Rho-associated protein kinase 1 | Rho-associated, coiled-coil-containing protein kinase 1 | Rho-associated, coiled-coil-containing protein kinase I | ROCK-I | ROCK1

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Enzyme / Kinase / Protein Kinase / AGC protein kinase group / AGC protein kinase DMPK family / AGC protein kinase ROCK subfamily

Target Relations

ALA IDRelationshipPref NameTarget Type
ALA2111459SUBSET OFRho-associated protein kinasePROTEIN FAMILY

Target Components

DescriptionRelationshipAccession
Rho-associated protein kinase 1PROTEINQ13464

Associated Antibodies

NameSpecificationsSpecies reactivityspeciesApplicationView Details

Associated Active Ligands

  1. Tetrahydrouridine
    ALA375877

    Name:
    4-(1-ethyl-6-phenoxy-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine

    Mol. Formula:
    C16H14N6O2

    M.W.:
    322.33

    Type:
    Small molecule

    AlogP:
    2.88

    Polar Surface Area:
    104.88

    HBA:
    8

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.62

    DETAILS
  2. Tetrahydrouridine
    ALA218868

    Name:
    4-(1-ethyl-6-(3-acetylaminophenoxy)-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine

    Mol. Formula:
    C18H17N7O3

    M.W.:
    379.38

    Type:
    Small molecule

    AlogP:
    2.83

    Polar Surface Area:
    133.98

    HBA:
    9

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.54

    DETAILS
  3. Tetrahydrouridine
    ALA218869

    Name:
    4-(1-ethyl-6-(4-acetylaminophenoxy)-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine

    Mol. Formula:
    C18H17N7O3

    M.W.:
    379.38

    Type:
    Small molecule

    AlogP:
    2.83

    Polar Surface Area:
    133.98

    HBA:
    9

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.54

    DETAILS
  4. Tetrahydrouridine
    ALA387338

    Name:
    1-(3-{[2-(4-Amino-furazan-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)ethanone

    Mol. Formula:
    C18H16N6O3

    M.W.:
    364.37

    Type:
    Small molecule

    AlogP:
    3.08

    Polar Surface Area:
    121.95

    HBA:
    9

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.54

    DETAILS
  5. Tetrahydrouridine
    ALA220408

    Name:
    4-(1-ethyl-6-{[3-(methylsulfonyl)phenyl]oxy}-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine

    Mol. Formula:
    C17H16N6O4S

    M.W.:
    400.42

    Type:
    Small molecule

    AlogP:
    2.28

    Polar Surface Area:
    139.02

    HBA:
    10

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.53

    DETAILS
  6. Tetrahydrouridine
    ALA373419

    Name:
    4-{6-[(3-aminophenyl)oxy]-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl}-1,2,5-oxadiazol-3-amine

    Mol. Formula:
    C16H15N7O2

    M.W.:
    337.34

    Type:
    Small molecule

    AlogP:
    2.46

    Polar Surface Area:
    130.90

    HBA:
    9

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.54

    DETAILS
  7. Tetrahydrouridine
    ALA426526

    Name:
    N-(3-{[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)benzamide

    Mol. Formula:
    C23H19N7O3

    M.W.:
    441.45

    Type:
    Small molecule

    AlogP:
    4.13

    Polar Surface Area:
    133.98

    HBA:
    9

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.40

    DETAILS
  8. Tetrahydrouridine
    ALA220465

    Name:
    N-(3-{[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-4-(dimethylamino)benzamide

    Mol. Formula:
    C25H24N8O3

    M.W.:
    484.52

    Type:
    Small molecule

    AlogP:
    4.19

    Polar Surface Area:
    137.22

    HBA:
    10

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.35

    DETAILS
  9. Tetrahydrouridine
    ALA220241

    Name:
    N-(3-{[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-4-{[2-(4-morpholinyl)ethyl]oxy}benzamide

    Mol. Formula:
    C29H30N8O5

    M.W.:
    570.61

    Type:
    Small molecule

    AlogP:
    3.84

    Polar Surface Area:
    155.68

    HBA:
    12

    HBD:
    2

    #RO5 Violations:
    2

    #Rotatable Bonds:
    10

    Passes Ro3:
    N

    QED Weighted:
    0.25

    DETAILS
  10. Tetrahydrouridine
    ALA216574

    Name:
    N-(3-{[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-4-(4-morpholinyl)benzamide

    Mol. Formula:
    C27H26N8O4

    M.W.:
    526.56

    Type:
    Small molecule

    AlogP:
    3.96

    Polar Surface Area:
    146.45

    HBA:
    11

    HBD:
    2

    #RO5 Violations:
    2

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.32

    DETAILS