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Inhibitor of nuclear factor kappa B kinase alpha subunit

Name And Classification

ID:  ALA3476

Type:  SINGLE PROTEIN

Synonyms:   2.7.11.10 | CHUK | Conserved helix-loop-helix ubiquitous kinase | I-kappa-B kinase 1 | I-kappa-B kinase alpha | IkappaB kinase | IkBKA | IKK-1 | IKK-A | IKK-alpha | IKK1 | IKKA | Inhibitor of nuclear factor kappa-B kinase subunit alpha | NFKBIKA | Nuclear factor NF-kappa-B inhibitor kinase alpha | TCF-16 | TCF16 | Transcription factor 16

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Enzyme / Kinase / Protein Kinase / Other protein kinase group

Target Relations

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ALA IDRelationshipPref NameTarget Type

Target Components

DescriptionRelationshipAccession
Inhibitor of nuclear factor kappa-B kinase subunit alphaPROTEINO15111

Associated Recombinant Proteins

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NameSpecification and purityExpression systemProtein labelActivityView Details

Associated Antibodies

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NameSpecificationsSpecies reactivityspeciesApplicationView Details

Associated Active Ligands

  1. Tetrahydrouridine
    ALA309265

    Name:
    N-(6-Chloro-9H-beta-carbolin-8-yl)-benzenesulfonamide

    Mol. Formula:
    C17H12ClN3O2S

    M.W.:
    357.82

    Type:
    Small molecule

    AlogP:
    4.17

    Polar Surface Area:
    74.85

    HBA:
    3

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.58

    DETAILS
  2. Tetrahydrouridine
    ALA312676

    Name:
    N-(6-Chloro-9H-beta-carbolin-8-yl)-methanesulfonamide

    Mol. Formula:
    C12H10ClN3O2S

    M.W.:
    295.75

    Type:
    Small molecule

    AlogP:
    2.69

    Polar Surface Area:
    74.85

    HBA:
    3

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.76

    DETAILS
  3. Tetrahydrouridine
    ALA78885

    Name:
    N-(6-Chloro-9H-beta-carbolin-8-yl)-4-methoxy-benzamide

    Mol. Formula:
    C19H14ClN3O2

    M.W.:
    351.79

    Type:
    Small molecule

    AlogP:
    4.58

    Polar Surface Area:
    67.01

    HBA:
    3

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.57

    DETAILS
  4. Tetrahydrouridine
    ALA311201

    Name:
    6-Chloro-9H-beta-carboline

    Mol. Formula:
    C11H7ClN2

    M.W.:
    202.64

    Type:
    Small molecule

    AlogP:
    3.37

    Polar Surface Area:
    28.68

    HBA:
    1

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    0

    Passes Ro3:
    N

    QED Weighted:
    0.60

    DETAILS
  5. Tetrahydrouridine
    ALA81229

    Name:
    6,8-Dichloro-7-ethoxy-9H-beta-carboline

    Mol. Formula:
    C13H10Cl2N2O

    M.W.:
    281.14

    Type:
    Small molecule

    AlogP:
    4.37

    Polar Surface Area:
    37.91

    HBA:
    2

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.76

    DETAILS
  6. Tetrahydrouridine
    ALA312651

    Name:
    6,8-Dichloro-7-methoxy-9H-beta-carboline

    Mol. Formula:
    C12H8Cl2N2O

    M.W.:
    267.12

    Type:
    Small molecule

    AlogP:
    3.98

    Polar Surface Area:
    37.91

    HBA:
    2

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    1

    Passes Ro3:
    N

    QED Weighted:
    0.72

    DETAILS
  7. Tetrahydrouridine
    ALA78464

    Name:
    6,8-Dichloro-9H-beta-carboline

    Mol. Formula:
    C11H6Cl2N2

    M.W.:
    237.09

    Type:
    Small molecule

    AlogP:
    4.02

    Polar Surface Area:
    28.68

    HBA:
    1

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    0

    Passes Ro3:
    N

    QED Weighted:
    0.63

    DETAILS
  8. Tetrahydrouridine
    ALA78618

    Name:
    6-Trifluoromethyl-9H-beta-carboline

    Mol. Formula:
    C12H7F3N2

    M.W.:
    236.20

    Type:
    Small molecule

    AlogP:
    3.73

    Polar Surface Area:
    28.68

    HBA:
    1

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    0

    Passes Ro3:
    N

    QED Weighted:
    0.63

    DETAILS
  9. Tetrahydrouridine
    ALA81214

    Name:
    9H-beta-Carboline-6-carbonitrile

    Mol. Formula:
    C12H7N3

    M.W.:
    193.21

    Type:
    Small molecule

    AlogP:
    2.59

    Polar Surface Area:
    52.47

    HBA:
    2

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    0

    Passes Ro3:
    Y

    QED Weighted:
    0.60

    DETAILS
  10. Tetrahydrouridine
    ALA81169

    Name:
    6-Bromo-9H-beta-carboline

    Mol. Formula:
    C11H7BrN2

    M.W.:
    247.09

    Type:
    Small molecule

    AlogP:
    3.48

    Polar Surface Area:
    28.68

    HBA:
    1

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    0

    Passes Ro3:
    N

    QED Weighted:
    0.65

    DETAILS