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Neutral amino acid transporter B(0)

Name And Classification

ID:  ALA3562162

Type:  SINGLE PROTEIN

Synonyms:   ASCT2 | ATB(0) | Baboon M7 virus receptor | M7V1 | Neutral amino acid transporter B(0) | RD114/simian type D retrovirus receptor | RDR | RDRC | SLC1A5 | Sodium-dependent neutral amino acid transporter type 2 | Solute carrier family 1 member 5 | Synonyms=ASCT2

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Transporter / Electrochemical transporter / SLC superfamily of solute carriers / SLC06 neurotransmitter transporter family

Target Components

DescriptionRelationshipAccession
Neutral amino acid transporter B(0)PROTEINQ15758

Associated Active Ligands

  1. Tetrahydrouridine
    ALA3576926

    Name:
    (S)-2-amino-5-(2-benzylphenylamino)-5-oxopentanoic acid

    Mol. Formula:
    C18H20N2O3

    M.W.:
    312.37

    Type:
    Small molecule

    AlogP:
    2.41

    Polar Surface Area:
    92.42

    HBA:
    3

    HBD:
    3

    #RO5 Violations:
    0

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.73

    DETAILS
  2. Tetrahydrouridine
    ALA3576927

    Name:
    (S)-2-amino-5-(2-morpholinophenylamino)-5-oxopentanoic acid

    Mol. Formula:
    C15H21N3O4

    M.W.:
    307.35

    Type:
    Small molecule

    AlogP:
    0.65

    Polar Surface Area:
    104.89

    HBA:
    5

    HBD:
    3

    #RO5 Violations:
    0

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.71

    DETAILS
  3. Tetrahydrouridine
    ALA3576928

    Name:
    (S)-2-amino-5-(2-(benzo[d]thiazol-2-yl)phenylamino)-5-oxopentanoic acid

    Mol. Formula:
    C18H17N3O3S

    M.W.:
    355.42

    Type:
    Small molecule

    AlogP:
    3.09

    Polar Surface Area:
    105.31

    HBA:
    5

    HBD:
    3

    #RO5 Violations:
    0

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.63

    DETAILS
  4. Tetrahydrouridine
    ALA3576929

    Name:
    (S)-2-amino-5-(2-(morpholinomethyl)phenylamino)-5-oxopentanoic acid

    Mol. Formula:
    C16H23N3O4

    M.W.:
    321.38

    Type:
    Small molecule

    AlogP:
    0.65

    Polar Surface Area:
    104.89

    HBA:
    5

    HBD:
    3

    #RO5 Violations:
    0

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.68

    DETAILS
  5. Tetrahydrouridine
    ALA3576930

    Name:
    (S)-2-amino-5-oxo-5-(2-(pyrrolidin-1-ylmethyl)phenylamino)pentanoic acid

    Mol. Formula:
    C16H23N3O3

    M.W.:
    305.38

    Type:
    Small molecule

    AlogP:
    1.41

    Polar Surface Area:
    95.66

    HBA:
    4

    HBD:
    3

    #RO5 Violations:
    0

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.71

    DETAILS
  6. Tetrahydrouridine
    ALA3576931

    Name:
    (S)-2-amino-5-oxo-5-(2-(piperazin-1-yl)phenylamino)pentanoic acid

    Mol. Formula:
    C15H22N4O3

    M.W.:
    306.37

    Type:
    Small molecule

    AlogP:
    0.23

    Polar Surface Area:
    107.69

    HBA:
    5

    HBD:
    4

    #RO5 Violations:
    0

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.60

    DETAILS
  7. Tetrahydrouridine
    ALA3576932

    Name:
    (S)-2-amino-5-(biphenyl-2-ylamino)-5-oxopentanoic acid

    Mol. Formula:
    C17H18N2O3

    M.W.:
    298.34

    Type:
    Small molecule

    AlogP:
    2.48

    Polar Surface Area:
    92.42

    HBA:
    3

    HBD:
    3

    #RO5 Violations:
    0

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.76

    DETAILS
  8. Tetrahydrouridine
    ALA3576933

    Name:
    (S)-2-amino-5-(3-morpholinophenylamino)-5-oxopentanoic acid

    Mol. Formula:
    C15H21N3O4

    M.W.:
    307.35

    Type:
    Small molecule

    AlogP:
    0.65

    Polar Surface Area:
    104.89

    HBA:
    5

    HBD:
    3

    #RO5 Violations:
    0

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.71

    DETAILS
  9. Tetrahydrouridine
    ALA3576934

    Name:
    (S)-2-amino-5-(2-(4-methylpiperazin-1-yl)phenylamino)-5-oxopentanoic acid

    Mol. Formula:
    C16H24N4O3

    M.W.:
    320.39

    Type:
    Small molecule

    AlogP:
    0.57

    Polar Surface Area:
    98.90

    HBA:
    5

    HBD:
    3

    #RO5 Violations:
    0

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.71

    DETAILS
  10. Tetrahydrouridine
    ALA3576935

    Name:
    (S)-2-amino-5-(4-morpholinophenylamino)-5-oxopentanoic acid

    Mol. Formula:
    C15H21N3O4

    M.W.:
    307.35

    Type:
    Small molecule

    AlogP:
    0.65

    Polar Surface Area:
    104.89

    HBA:
    5

    HBD:
    3

    #RO5 Violations:
    0

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.71

    DETAILS