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Baculoviral IAP repeat-containing protein 3/Huntingtin

Name And Classification

ID:  ALA4296121

Type:  PROTEIN-PROTEIN INTERACTION

Synonyms:   2.3.2.27 | API2 | API2 | Apoptosis inhibitor 2 | Baculoviral IAP repeat-containing protein 3 | BIRC3 | C-IAP2 | Cellular inhibitor of apoptosis 2 | hIAP-1 | hIAP1 | IAP homolog C | Inhibitor of apoptosis protein 1 | MIHC | RING finger protein 49 | RING-type E3 ubiquitin transferase BIRC3 | RNF49 | TNFR2-TRAF-signaling complex protein 1

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Enzyme

Target Relations

ALA IDRelationshipPref NameTarget Type
ALA5514SUPERSET OFHuntingtinSINGLE PROTEIN
ALA3038465OVERLAPS WITHcIAP1/cIAP2PROTEIN FAMILY
ALA5335SUPERSET OFBaculoviral IAP repeat-containing protein 3SINGLE PROTEIN
ALA3885522OVERLAPS WITHBaculoviral IAP repeat-containing protein 3/Mucosa-associated lymphoid tissue lymphoma translocation protein 1CHIMERIC PROTEIN

Target Components

DescriptionRelationshipAccession
Baculoviral IAP repeat-containing protein 3PROTEINQ13489
HuntingtinPROTEINP42858

Associated Active Ligands

  1. Tetrahydrouridine
    ALA4208207

    Name:
    (S)-2-((2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido)-N-(2-(2-(2-(2-((4-(dimethylamino)phenyl)diazenyl)benzo[d]thiazol-6-yloxy)ethoxy)ethoxy)ethyl)-4-methylpentanamide

    Mol. Formula:
    C37H49N7O6S

    M.W.:
    719.91

    Type:
    Small molecule

    AlogP:
    4.77

    Polar Surface Area:
    172.99

    HBA:
    12

    HBD:
    4

    #RO5 Violations:
    2

    #Rotatable Bonds:
    21

    Passes Ro3:
    N

    QED Weighted:
    0.07

    DETAILS
  2. Tetrahydrouridine
    ALA4213125

    Name:
    (S)-2-((2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido)-4-methyl-N-(2-(2-(2-(4-(6-methylbenzo[d]thiazol-2-yl)phenylamino)ethoxy)ethoxy)ethyl)pentanamide

    Mol. Formula:
    C36H47N5O5S

    M.W.:
    661.87

    Type:
    Small molecule

    AlogP:
    4.29

    Polar Surface Area:
    147.83

    HBA:
    9

    HBD:
    5

    #RO5 Violations:
    1

    #Rotatable Bonds:
    19

    Passes Ro3:
    N

    QED Weighted:
    0.09

    DETAILS
  3. Tetrahydrouridine
    ALA4217540

    Name:
    (S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-N-((S)-1-(2-(2-(2-(2-((4-(dimethylamino)phenyl)diazenyl)benzo[d]thiazol-6-yloxy)ethoxy)ethoxy)ethylamino)-1-oxo-3,3-diphenylpropan-2-yl)pyrrolidine-2-carboxamide

    Mol. Formula:
    C53H67N9O7S

    M.W.:
    974.24

    Type:
    Small molecule

    AlogP:
    7.29

    Polar Surface Area:
    188.18

    HBA:
    13

    HBD:
    4

    #RO5 Violations:
    3

    #Rotatable Bonds:
    24

    Passes Ro3:
    N

    QED Weighted:
    0.04

    DETAILS