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Voltage-gated N-type calcium channel alpha-1B subunit

Name And Classification

ID:  ALA4478

Type:  SINGLE PROTEIN

Synonyms:   BIII | Brain calcium channel III | CACH5 | CACNA1B | CACNL1A5 | Calcium channel, L type, alpha-1 polypeptide isoform 5 | Voltage-dependent N-type calcium channel subunit alpha-1B | Voltage-gated calcium channel subunit alpha Cav2.2

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Ion channel / Voltage-gated ion channel / Voltage-gated calcium channel

Target Relations

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ALA IDRelationshipPref NameTarget Type

Target Components

DescriptionRelationshipAccession
Voltage-dependent N-type calcium channel subunit alpha-1BPROTEINQ00975

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelActivityView Details

Associated Active Ligands

  1. Tetrahydrouridine
    ALA13959

    Name:
    Benzoic acid 4-((S)-2-tert-butoxycarbonyl-2-{[4-methyl-1-(3-methyl-butyl)-piperidine-2-carbonyl]-amino}-ethyl)-phenyl ester

    Mol. Formula:
    C32H44N2O5

    M.W.:
    536.71

    Type:
    Small molecule

    AlogP:
    5.42

    Polar Surface Area:
    84.94

    HBA:
    6

    HBD:
    1

    #RO5 Violations:
    2

    #Rotatable Bonds:
    10

    Passes Ro3:
    N

    QED Weighted:
    0.32

    DETAILS
  2. Tetrahydrouridine
    ALA14091

    Name:
    Benzoic acid 4-((S)-2-tert-butylcarbamoyl-2-{2-[methyl-(3-methyl-butyl)-amino]-acetylamino}-ethyl)-phenyl ester

    Mol. Formula:
    C28H39N3O4

    M.W.:
    481.64

    Type:
    Small molecule

    AlogP:
    3.83

    Polar Surface Area:
    87.74

    HBA:
    5

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    11

    Passes Ro3:
    N

    QED Weighted:
    0.38

    DETAILS
  3. Tetrahydrouridine
    ALA13674

    Name:
    Benzoic acid 4-((S)-2-tert-butoxycarbonyl-2-{[6-methyl-1-(3-methyl-butyl)-piperidine-2-carbonyl]-amino}-ethyl)-phenyl ester

    Mol. Formula:
    C32H44N2O5

    M.W.:
    536.71

    Type:
    Small molecule

    AlogP:
    5.56

    Polar Surface Area:
    84.94

    HBA:
    6

    HBD:
    1

    #RO5 Violations:
    2

    #Rotatable Bonds:
    10

    Passes Ro3:
    N

    QED Weighted:
    0.32

    DETAILS
  4. Tetrahydrouridine
    ALA273893

    Name:
    Benzoic acid 4-((S)-2-tert-butoxycarbonyl-2-{[1-(3-methyl-butyl)-piperidine-4-carbonyl]-amino}-ethyl)-phenyl ester

    Mol. Formula:
    C31H42N2O5

    M.W.:
    522.69

    Type:
    Small molecule

    AlogP:
    5.03

    Polar Surface Area:
    84.94

    HBA:
    6

    HBD:
    1

    #RO5 Violations:
    2

    #Rotatable Bonds:
    10

    Passes Ro3:
    N

    QED Weighted:
    0.35

    DETAILS
  5. Tetrahydrouridine
    ALA13798

    Name:
    Benzoic acid 4-((S)-2-tert-butoxycarbonyl-2-{[4-isopropyl-1-(3-methyl-butyl)-piperidine-2-carbonyl]-amino}-ethyl)-phenyl ester

    Mol. Formula:
    C34H48N2O5

    M.W.:
    564.77

    Type:
    Small molecule

    AlogP:
    6.06

    Polar Surface Area:
    84.94

    HBA:
    6

    HBD:
    1

    #RO5 Violations:
    2

    #Rotatable Bonds:
    11

    Passes Ro3:
    N

    QED Weighted:
    0.26

    DETAILS
  6. Tetrahydrouridine
    ALA13944

    Name:
    Benzoic acid 4-((S)-2-tert-butoxycarbonyl-2-{[1-(3-methyl-butyl)-piperidine-2-carbonyl]-amino}-ethyl)-phenyl ester

    Mol. Formula:
    C31H42N2O5

    M.W.:
    522.69

    Type:
    Small molecule

    AlogP:
    5.18

    Polar Surface Area:
    84.94

    HBA:
    6

    HBD:
    1

    #RO5 Violations:
    2

    #Rotatable Bonds:
    10

    Passes Ro3:
    N

    QED Weighted:
    0.34

    DETAILS
  7. Tetrahydrouridine
    ALA273705

    Name:
    Benzoic acid 4-((S)-2-tert-butylcarbamoyl-2-{(S)-3-methyl-2-[methyl-(3-methyl-butyl)-amino]-butyrylamino}-ethyl)-phenyl ester

    Mol. Formula:
    C31H45N3O4

    M.W.:
    523.72

    Type:
    Small molecule

    AlogP:
    4.85

    Polar Surface Area:
    87.74

    HBA:
    5

    HBD:
    2

    #RO5 Violations:
    1

    #Rotatable Bonds:
    12

    Passes Ro3:
    N

    QED Weighted:
    0.31

    DETAILS
  8. Tetrahydrouridine
    ALA277085

    Name:
    Benzoic acid 4-((S)-2-tert-butylcarbamoyl-2-{(S)-4-methyl-2-[methyl-(3-methyl-butyl)-amino]-pentanoylamino}-ethyl)-phenyl ester

    Mol. Formula:
    C32H47N3O4

    M.W.:
    537.75

    Type:
    Small molecule

    AlogP:
    5.24

    Polar Surface Area:
    87.74

    HBA:
    5

    HBD:
    2

    #RO5 Violations:
    2

    #Rotatable Bonds:
    13

    Passes Ro3:
    N

    QED Weighted:
    0.27

    DETAILS
  9. Tetrahydrouridine
    ALA275614

    Name:
    Benzoic acid 4-((S)-2-tert-butoxycarbonyl-2-{[4-methyl-1-(3-methyl-butyl)-piperazine-2-carbonyl]-amino}-ethyl)-phenyl ester

    Mol. Formula:
    C31H43N3O5

    M.W.:
    537.70

    Type:
    Small molecule

    AlogP:
    3.94

    Polar Surface Area:
    88.18

    HBA:
    7

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    10

    Passes Ro3:
    N

    QED Weighted:
    0.36

    DETAILS
  10. Tetrahydrouridine
    ALA13989

    Name:
    Benzoic acid 4-((S)-2-tert-butoxycarbonyl-2-{[3-methyl-1-(3-methyl-butyl)-piperidine-2-carbonyl]-amino}-ethyl)-phenyl ester

    Mol. Formula:
    C32H44N2O5

    M.W.:
    536.71

    Type:
    Small molecule

    AlogP:
    5.42

    Polar Surface Area:
    84.94

    HBA:
    6

    HBD:
    1

    #RO5 Violations:
    2

    #Rotatable Bonds:
    10

    Passes Ro3:
    N

    QED Weighted:
    0.32

    DETAILS