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Metabotropic glutamate receptor 6

Name And Classification

ID:  ALA4573

Type:  SINGLE PROTEIN

Synonyms:   GPRC1F | GRM6 | Metabotropic glutamate receptor 6 | MGLUR6 | mGluR6

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Membrane receptor / Family C G protein-coupled receptor / Small molecule receptor (family C GPCR) / Neurotransmitter receptor (family C GPCR) / Metabotropic glutamate receptor

Target Components

DescriptionRelationshipAccession
Metabotropic glutamate receptor 6PROTEINO15303

Associated Active Ligands

  1. Tetrahydrouridine
    ALA79393

    Name:
    (S)-3-Methyl-1,2,3,4-tetrahydro-isoquinoline-3,6-dicarboxylic acid

    Mol. Formula:
    C12H13NO4

    M.W.:
    235.24

    Type:
    Small molecule

    AlogP:
    0.87

    Polar Surface Area:
    86.63

    HBA:
    3

    HBD:
    3

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.71

    DETAILS
  2. Tetrahydrouridine
    ALA81147

    Name:
    (S)-2-Amino-2-methyl-3-(3-phosphono-phenyl)-propionic acid

    Mol. Formula:
    C10H14NO5P

    M.W.:
    259.20

    Type:
    Small molecule

    AlogP:
    -0.17

    Polar Surface Area:
    120.85

    HBA:
    3

    HBD:
    4

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.56

    DETAILS
  3. Tetrahydrouridine
    ALA4063142

    Name:
    [((3S)-3-Amino-3-carboxy)propyl][(3-nitro-4-trifluoromethylphenyl)hydroxymethyl]phosphinic Acid

    Mol. Formula:
    C12H14F3N2O7P

    M.W.:
    386.22

    Type:
    Small molecule

    AlogP:
    1.68

    Polar Surface Area:
    163.99

    HBA:
    6

    HBD:
    4

    #RO5 Violations:
    0

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.31

    DETAILS
  4. Tetrahydrouridine
    ALA4063720

    Name:
    [((3S,1'S)-3-Amino-3-carboxy)propyl][(4-methoxy-3-nitrophenyl)hydroxymethyl]phosphinic Acid

    Mol. Formula:
    C12H17N2O8P

    M.W.:
    348.25

    Type:
    Small molecule

    AlogP:
    0.67

    Polar Surface Area:
    173.22

    HBA:
    7

    HBD:
    4

    #RO5 Violations:
    0

    #Rotatable Bonds:
    8

    Passes Ro3:
    N

    QED Weighted:
    0.30

    DETAILS
  5. Tetrahydrouridine
    ALA4072316

    Name:
    [((3S,1'S)-3-Amino-3-carboxy)propyl][(4-hydroxy-3-nitrophenyl)hydroxymethyl]phosphinic Acid

    Mol. Formula:
    C11H15N2O8P

    M.W.:
    334.22

    Type:
    Small molecule

    AlogP:
    0.36

    Polar Surface Area:
    184.22

    HBA:
    7

    HBD:
    5

    #RO5 Violations:
    0

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.27

    DETAILS
  6. Tetrahydrouridine
    ALA4081842

    Name:
    [((3S,1'S)-3-Amino-3-carboxy)propyl][(4-hydroxy-5-methoxy-3-nitrophenyl)hydroxymethyl]phosphinic Acid

    Mol. Formula:
    C12H17N2O9P

    M.W.:
    364.25

    Type:
    Small molecule

    AlogP:
    0.37

    Polar Surface Area:
    193.45

    HBA:
    8

    HBD:
    5

    #RO5 Violations:
    0

    #Rotatable Bonds:
    8

    Passes Ro3:
    N

    QED Weighted:
    0.24

    DETAILS
  7. Tetrahydrouridine
    ALA4082270

    Name:
    [((3S)-3-Amino-3-carboxy)propyl][(4-morpholino-3-nitrophenyl)hydroxymethyl]phosphinic Acid

    Mol. Formula:
    C15H22N3O8P

    M.W.:
    403.33

    Type:
    Small molecule

    AlogP:
    0.49

    Polar Surface Area:
    176.46

    HBA:
    8

    HBD:
    4

    #RO5 Violations:
    0

    #Rotatable Bonds:
    8

    Passes Ro3:
    N

    QED Weighted:
    0.27

    DETAILS
  8. Tetrahydrouridine
    ALA4082813

    Name:
    [((3S)-3-Amino-3-carboxy)propyl][(4-hydroxy-3-nitrophenyl)methyl]phosphinic Acid

    Mol. Formula:
    C11H15N2O7P

    M.W.:
    318.22

    Type:
    Small molecule

    AlogP:
    0.87

    Polar Surface Area:
    163.99

    HBA:
    6

    HBD:
    4

    #RO5 Violations:
    0

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.33

    DETAILS
  9. Tetrahydrouridine
    ALA4085327

    Name:
    [((3S,1'R)-3-Amino-3-carboxy)propyl][(4-methoxy-3-nitrophenyl)hydroxymethyl]phosphinic Acid

    Mol. Formula:
    C12H17N2O8P

    M.W.:
    348.25

    Type:
    Small molecule

    AlogP:
    0.67

    Polar Surface Area:
    173.22

    HBA:
    7

    HBD:
    4

    #RO5 Violations:
    0

    #Rotatable Bonds:
    8

    Passes Ro3:
    N

    QED Weighted:
    0.30

    DETAILS
  10. Tetrahydrouridine
    ALA4085558

    Name:
    [((3S,1'R)-3-Amino-3-carboxy)propyl][(4-hydroxy-5-methoxy-3-nitrophenyl)hydroxymethyl]phosphinic Acid

    Mol. Formula:
    C12H17N2O9P

    M.W.:
    364.25

    Type:
    Small molecule

    AlogP:
    0.37

    Polar Surface Area:
    193.45

    HBA:
    8

    HBD:
    5

    #RO5 Violations:
    0

    #Rotatable Bonds:
    8

    Passes Ro3:
    N

    QED Weighted:
    0.24

    DETAILS