ID: ALA4625
Type: SINGLE PROTEIN
Synonyms: Apoptosis regulator Bcl-X | Bcl-2-like protein 1 | Bcl2-L-1 | BCL2L | BCL2L1 | BCLX
Organism: Homo sapiens
Species Group: Homo sapiens
Protein Target Classification: Ion channel / Other ion channel / Miscellaneous ion channel / Bcl-2 family
ALA ID | Relationship | Pref Name | Target Type |
---|---|---|---|
ALA3883285 | SUBSET OF | Bcl-xL/BH3-interacting domain death agonist | PROTEIN-PROTEIN INTERACTION |
ALA3883287 | SUBSET OF | Bcl-xL/Bcl-2-like protein 11 | PROTEIN-PROTEIN INTERACTION |
ALA3883286 | SUBSET OF | Bcl-xL/BAX | PROTEIN-PROTEIN INTERACTION |
ALA3137283 | SUBSET OF | Bcl-xL/BAK | PROTEIN-PROTEIN INTERACTION |
ALA3883288 | SUBSET OF | Bcl-xL/Bcl-2-binding component 3 | PROTEIN-PROTEIN INTERACTION |
ALA4748229 | SUBSET OF | VHL/Bcl-2-like protein 1 | PROTEIN-PROTEIN INTERACTION |
ALA4523705 | SUBSET OF | Protein cereblon/Bcl-2-like protein 1 | PROTEIN-PROTEIN INTERACTION |
Description | Relationship | Accession |
---|---|---|
Bcl-2-like protein 1 | PROTEIN | Q07817 |
Name:
(S)-2-[4-(1-Carboxy-3-methyl-butylcarbamoyl)-2-(naphthalen-1-yloxy)-benzoylamino]-4-methyl-pentanoic acid
Mol. Formula:
C30H34N2O7
M.W.:
534.61
Type:
Small molecule
AlogP:
5.09
Polar Surface Area:
142.03
HBA:
5
HBD:
4
#RO5 Violations:
2
#Rotatable Bonds:
12
Passes Ro3:
N
QED Weighted:
0.25
Name:
(S)-2-(4-Diisopropylcarbamoyl-2-isopropoxy-benzoylamino)-4-methyl-pentanoic acid methyl ester
Mol. Formula:
C24H38N2O5
M.W.:
434.58
Type:
Small molecule
AlogP:
4.05
Polar Surface Area:
84.94
HBA:
5
HBD:
1
#RO5 Violations:
0
#Rotatable Bonds:
10
Passes Ro3:
N
QED Weighted:
0.56
Name:
(S)-2-(4-Diisopropylcarbamoyl-2-isopropoxy-benzoylamino)-4-methyl-pentanoic acid
Mol. Formula:
C23H36N2O5
M.W.:
420.55
Type:
Small molecule
AlogP:
3.96
Polar Surface Area:
95.94
HBA:
4
HBD:
2
#RO5 Violations:
0
#Rotatable Bonds:
10
Passes Ro3:
N
QED Weighted:
0.60
Name:
(S)-2-[4-Diisopropylcarbamoyl-2-(naphthalen-1-yloxy)-benzoylamino]-4-methyl-pentanoic acid
Mol. Formula:
C30H36N2O5
M.W.:
504.63
Type:
Small molecule
AlogP:
6.12
Polar Surface Area:
95.94
HBA:
4
HBD:
2
#RO5 Violations:
2
#Rotatable Bonds:
10
Passes Ro3:
N
QED Weighted:
0.35
Name:
(R)-2-(4-Diisopropylcarbamoyl-2-methoxy-benzoylamino)-4-methyl-pentanoic acid methyl ester
Mol. Formula:
C22H34N2O5
M.W.:
406.52
Type:
Small molecule
AlogP:
3.27
Polar Surface Area:
84.94
HBA:
5
HBD:
1
#RO5 Violations:
0
#Rotatable Bonds:
9
Passes Ro3:
N
QED Weighted:
0.64
Name:
(S)-2-(4-Diisopropylcarbamoyl-2-isopropylamino-benzoylamino)-4-methyl-pentanoic acid
Mol. Formula:
C23H37N3O4
M.W.:
419.57
Type:
Small molecule
AlogP:
4.00
Polar Surface Area:
98.74
HBA:
4
HBD:
3
#RO5 Violations:
0
#Rotatable Bonds:
10
Passes Ro3:
N
QED Weighted:
0.53
Name:
(4-Dimethylcarbamoyl-benzoylamino)-acetic acid methyl ester
Mol. Formula:
C13H16N2O4
M.W.:
264.28
Type:
Small molecule
AlogP:
0.29
Polar Surface Area:
75.71
HBA:
4
HBD:
1
#RO5 Violations:
0
#Rotatable Bonds:
4
Passes Ro3:
N
QED Weighted:
0.79
Name:
(S)-2-[4-(1-Carboxy-3-methyl-butylcarbamoyl)-2-phenoxy-benzoylamino]-4-methyl-pentanoic acid
Mol. Formula:
C26H32N2O7
M.W.:
484.55
Type:
Small molecule
AlogP:
3.94
Polar Surface Area:
142.03
HBA:
5
HBD:
4
#RO5 Violations:
0
#Rotatable Bonds:
12
Passes Ro3:
N
QED Weighted:
0.36
Name:
(S)-2-{4-[(1-Carboxy-2-methyl-propyl)-isobutyl-carbamoyl]-2-isopropoxy-benzoylamino}-4-methyl-pentanoic acid
Mol. Formula:
C26H40N2O7
M.W.:
492.61
Type:
Small molecule
AlogP:
3.91
Polar Surface Area:
133.24
HBA:
5
HBD:
3
#RO5 Violations:
0
#Rotatable Bonds:
13
Passes Ro3:
N
QED Weighted:
0.38
Name:
(S)-2-{4-[(1-Carboxy-ethyl)-isobutyl-carbamoyl]-2-isopropoxy-benzoylamino}-4-methyl-pentanoic acid
Mol. Formula:
C24H36N2O7
M.W.:
464.56
Type:
Small molecule
AlogP:
3.27
Polar Surface Area:
133.24
HBA:
5
HBD:
3
#RO5 Violations:
0
#Rotatable Bonds:
12
Passes Ro3:
N
QED Weighted:
0.43