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CRBN/AKT1

Name And Classification

ID:  ALA5169081

Type:  PROTEIN-PROTEIN INTERACTION

Synonyms:   2.7.11.1 | AKT1 | PKB | PKB | PKB alpha | Protein kinase B | Protein kinase B alpha | Proto-oncogene c-Akt | RAC | RAC-alpha serine/threonine-protein kinase | RAC-PK-alpha

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Enzyme / Kinase / Protein Kinase / AGC protein kinase group / AGC protein kinase AKT family

Target Relations

ALA IDRelationshipPref NameTarget Type
ALA5169068OVERLAPS WITHVHL/AKT1PROTEIN-PROTEIN INTERACTION
ALA4630728OVERLAPS WITHProtein cereblon/Tyrosine-protein kinase SRCPROTEIN-PROTEIN INTERACTION
ALA4630727OVERLAPS WITHProtein cereblon/Phosphodiesterase 6DPROTEIN-PROTEIN INTERACTION
ALA4630730OVERLAPS WITHProtein cereblon/Tyrosine-protein kinase receptor FLT3PROTEIN-PROTEIN INTERACTION
ALA4630729OVERLAPS WITHProtein cereblon/HMG-CoA reductasePROTEIN-PROTEIN INTERACTION
ALA4630732OVERLAPS WITHProtein cereblon/Serine/threonine-protein kinase WEE1PROTEIN-PROTEIN INTERACTION
ALA5169080OVERLAPS WITHCRBN/ADORA1PROTEIN-PROTEIN INTERACTION
ALA4630731OVERLAPS WITHProtein cereblon/Stem cell growth factor receptorPROTEIN-PROTEIN INTERACTION
ALA5169079OVERLAPS WITHCRBN/AXLPROTEIN-PROTEIN INTERACTION
ALA5169082OVERLAPS WITHCRBN/AKT2PROTEIN-PROTEIN INTERACTION

Target Components

DescriptionRelationshipAccession
RAC-alpha serine/threonine-protein kinasePROTEINP31749
Protein cereblonPROTEINQ96SW2

Associated Antibodies

NameSpecificationsSpecies reactivityspeciesApplicationView Details

Associated Active Ligands

  1. Tetrahydrouridine
    ALA5218521

    Name:
    3-(3-(3-(4-(1-Aminocyclobutyl)phenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-5-yl)phenyl)-N-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)propanamide

    Mol. Formula:
    C47H46N10O5

    M.W.:
    830.95

    AlogP:
    5.41

    Polar Surface Area:
    220.32

    HBA:
    12

    HBD:
    5

    #RO5 Violations:
    3

    #Rotatable Bonds:
    14

    Passes Ro3:
    N

    QED Weighted:
    0.07

    DETAILS
  2. Tetrahydrouridine
    ALA5218571

    Name:
    N-(3-(3-(4-(1-Aminocyclobutyl)phenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-5-yl)phenethyl)-4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butanamide

    Mol. Formula:
    C46H44N10O5

    M.W.:
    816.92

    AlogP:
    5.02

    Polar Surface Area:
    220.32

    HBA:
    12

    HBD:
    5

    #RO5 Violations:
    3

    #Rotatable Bonds:
    13

    Passes Ro3:
    N

    QED Weighted:
    0.08

    DETAILS
  3. Tetrahydrouridine
    ALA5218583

    Name:
    N-(3-(3-(4-(1-Aminocyclobutyl)phenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-5-yl)phenethyl)-3-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)propanamide

    Mol. Formula:
    C49H50N10O7

    M.W.:
    891.00

    AlogP:
    4.66

    Polar Surface Area:
    238.78

    HBA:
    14

    HBD:
    5

    #RO5 Violations:
    2

    #Rotatable Bonds:
    18

    Passes Ro3:
    N

    QED Weighted:
    0.06

    DETAILS
  4. Tetrahydrouridine
    ALA5218694

    Name:
    3-(3-(3-(4-(1-Aminocyclobutyl)phenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-5-yl)phenyl)-N-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)propanamide

    Mol. Formula:
    C47H46N10O6

    M.W.:
    846.95

    AlogP:
    4.65

    Polar Surface Area:
    229.55

    HBA:
    13

    HBD:
    5

    #RO5 Violations:
    2

    #Rotatable Bonds:
    15

    Passes Ro3:
    N

    QED Weighted:
    0.07

    DETAILS
  5. Tetrahydrouridine
    ALA5218725

    Name:
    3-(3-(3-(4-(1-aminocyclobutyl)phenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-5-yl)phenyl)-N-(7-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)heptyl)propanamide

    Mol. Formula:
    C50H52N10O5

    M.W.:
    873.03

    AlogP:
    6.58

    Polar Surface Area:
    220.32

    HBA:
    12

    HBD:
    5

    #RO5 Violations:
    3

    #Rotatable Bonds:
    17

    Passes Ro3:
    N

    QED Weighted:
    0.05

    DETAILS
  6. Tetrahydrouridine
    ALA5218831

    Name:
    N-(3-(3-(4-(1-Aminocyclobutyl)phenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-5-yl)phenethyl)-5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)pentanamide

    Mol. Formula:
    C47H46N10O5

    M.W.:
    830.95

    AlogP:
    5.41

    Polar Surface Area:
    220.32

    HBA:
    12

    HBD:
    5

    #RO5 Violations:
    3

    #Rotatable Bonds:
    14

    Passes Ro3:
    N

    QED Weighted:
    0.07

    DETAILS
  7. Tetrahydrouridine
    ALA5218917

    Name:
    3-(3-(3-(4-(1-Aminocyclobutyl)phenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-5-yl)phenyl)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)propanamide

    Mol. Formula:
    C45H42N10O5

    M.W.:
    802.90

    AlogP:
    4.63

    Polar Surface Area:
    220.32

    HBA:
    12

    HBD:
    5

    #RO5 Violations:
    2

    #Rotatable Bonds:
    12

    Passes Ro3:
    N

    QED Weighted:
    0.08

    DETAILS
  8. Tetrahydrouridine
    ALA5218989

    Name:
    N-(3-(3-(4-(1-Aminocyclobutyl)phenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-5-yl)phenethyl)-3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propanamide

    Mol. Formula:
    C47H46N10O6

    M.W.:
    846.95

    AlogP:
    4.65

    Polar Surface Area:
    229.55

    HBA:
    13

    HBD:
    5

    #RO5 Violations:
    2

    #Rotatable Bonds:
    15

    Passes Ro3:
    N

    QED Weighted:
    0.07

    DETAILS
  9. Tetrahydrouridine
    ALA5219172

    Name:
    N-(3-(3-(4-(1-Aminocyclobutyl)phenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-5-yl)phenethyl)-7-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)heptanamide

    Mol. Formula:
    C49H50N10O5

    M.W.:
    859.00

    AlogP:
    6.19

    Polar Surface Area:
    220.32

    HBA:
    12

    HBD:
    5

    #RO5 Violations:
    3

    #Rotatable Bonds:
    16

    Passes Ro3:
    N

    QED Weighted:
    0.05

    DETAILS
  10. Tetrahydrouridine
    ALA5219229

    Name:
    3-(3-(3-(4-(1-Aminocyclobutyl)phenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-5-yl)phenyl)-N-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)propanamide

    Mol. Formula:
    C49H50N10O7

    M.W.:
    891.00

    AlogP:
    4.66

    Polar Surface Area:
    238.78

    HBA:
    14

    HBD:
    5

    #RO5 Violations:
    2

    #Rotatable Bonds:
    18

    Passes Ro3:
    N

    QED Weighted:
    0.06

    DETAILS