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Neuropilin-1

Name And Classification

ID:  ALA5174

Type:  SINGLE PROTEIN

Synonyms:   CD_antigen=CD304 | Neuropilin-1 | NRP | NRP1 | Vascular endothelial cell growth factor 165 receptor | VEGF165R

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Secreted protein

Target Components

DescriptionRelationshipAccession
Neuropilin-1PROTEINO14786

Associated Active Ligands

  1. Tetrahydrouridine
    ALA215471

    Name:
    N-(5-chloro-1-cyano-2-phenylindolizin-3-yl)acetamide

    Mol. Formula:
    C17H12ClN3O

    M.W.:
    309.76

    Type:
    Small molecule

    AlogP:
    4.09

    Polar Surface Area:
    57.30

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.72

    DETAILS
  2. Tetrahydrouridine
    ALA425440

    Name:
    3-(3-aminophenylamino)-5-chloro-2-phenylindolizine-1-carbonitrile

    Mol. Formula:
    C21H15ClN4

    M.W.:
    358.83

    Type:
    Small molecule

    AlogP:
    5.46

    Polar Surface Area:
    66.25

    HBA:
    4

    HBD:
    2

    #RO5 Violations:
    1

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.38

    DETAILS
  3. Tetrahydrouridine
    ALA384861

    Name:
    5-chloro-2-(3-chlorophenyl)-3-(phenethylamino)indolizine-1-carbonitrile

    Mol. Formula:
    C23H17Cl2N3

    M.W.:
    406.32

    Type:
    Small molecule

    AlogP:
    6.44

    Polar Surface Area:
    40.23

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.39

    DETAILS
  4. Tetrahydrouridine
    ALA215962

    Name:
    5-chloro-2-(4-(methylthio)phenyl)-3-(phenethylamino)indolizine-1-carbonitrile

    Mol. Formula:
    C24H20ClN3S

    M.W.:
    417.96

    Type:
    Small molecule

    AlogP:
    6.51

    Polar Surface Area:
    40.23

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.29

    DETAILS
  5. Tetrahydrouridine
    ALA436932

    Name:
    5-chloro-3-(3-(dimethylamino)propylamino)-2-phenylindolizine-1-carbonitrile

    Mol. Formula:
    C20H21ClN4

    M.W.:
    352.87

    Type:
    Small molecule

    AlogP:
    4.49

    Polar Surface Area:
    43.47

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.52

    DETAILS
  6. Tetrahydrouridine
    ALA213321

    Name:
    5-chloro-3-(2,6-dimethylphenylamino)-2-phenylindolizine-1-carbonitrile

    Mol. Formula:
    C23H18ClN3

    M.W.:
    371.87

    Type:
    Small molecule

    AlogP:
    6.49

    Polar Surface Area:
    40.23

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.42

    DETAILS
  7. Tetrahydrouridine
    ALA213245

    Name:
    5-chloro-2-(2-methoxyphenyl)-3-(phenethylamino)indolizine-1-carbonitrile

    Mol. Formula:
    C24H20ClN3O

    M.W.:
    401.90

    Type:
    Small molecule

    AlogP:
    5.79

    Polar Surface Area:
    49.46

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.42

    DETAILS
  8. Tetrahydrouridine
    ALA377214

    Name:
    5-chloro-2-(2-chlorophenyl)-3-(phenethylamino)indolizine-1-carbonitrile

    Mol. Formula:
    C23H17Cl2N3

    M.W.:
    406.32

    Type:
    Small molecule

    AlogP:
    6.44

    Polar Surface Area:
    40.23

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.39

    DETAILS
  9. Tetrahydrouridine
    ALA379547

    Name:
    5-chloro-3-(4-(dimethylamino)phenylamino)-2-phenylindolizine-1-carbonitrile

    Mol. Formula:
    C23H19ClN4

    M.W.:
    386.89

    Type:
    Small molecule

    AlogP:
    5.94

    Polar Surface Area:
    43.47

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.44

    DETAILS
  10. Tetrahydrouridine
    ALA212851

    Name:
    3-(2-aminoethylamino)-5-chloro-2-phenylindolizine-1-carbonitrile

    Mol. Formula:
    C17H15ClN4

    M.W.:
    310.79

    Type:
    Small molecule

    AlogP:
    3.50

    Polar Surface Area:
    66.25

    HBA:
    4

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.72

    DETAILS