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DNA polymerase eta

Name And Classification

ID:  ALA5542

Type:  SINGLE PROTEIN

Synonyms:   2.7.7.7 | DNA polymerase eta | POLH | RAD30 | RAD30 homolog A | RAD30A | Xeroderma pigmentosum variant type protein | XPV

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Enzyme / Transferase

Target Components

DescriptionRelationshipAccession
DNA polymerase etaPROTEINQ9Y253

Associated Active Ligands

  1. Tetrahydrouridine
    ALA457041

    Name:
    4-[(2E)-but-2-enoyl]-2-[(1E,3E)-5-hydroxyhexa-1,3-dien-1-yl]-5-methoxy-2-methylfuran-3(2H)-one

    Mol. Formula:
    C16H20O5

    M.W.:
    292.33

    Type:
    Small molecule

    AlogP:
    1.84

    Polar Surface Area:
    72.83

    HBA:
    5

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.46

    DETAILS
  2. Tetrahydrouridine
    ALA513800

    Name:
    4-(3-hydroxybutanoyl)-2-[(1E,3E)-5-hydroxyhexa-1,3-dien-1-yl]-5-methoxy-2-methylfuran-3(2H)-one

    Mol. Formula:
    C16H22O6

    M.W.:
    310.35

    Type:
    Small molecule

    AlogP:
    1.04

    Polar Surface Area:
    93.06

    HBA:
    6

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.54

    DETAILS
  3. Tetrahydrouridine
    ALA500955

    Name:
    SID46500526

    Mol. Formula:
    C21H25NO4

    M.W.:
    355.43

    Type:
    Small molecule

    AlogP:
    4.36

    Polar Surface Area:
    68.54

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    8

    Passes Ro3:
    N

    QED Weighted:
    0.71

    DETAILS
  4. Tetrahydrouridine
    ALA1502144

    Name:
    SID26671673

    Mol. Formula:
    C13H16N6O4

    M.W.:
    320.31

    Type:
    Small molecule

    AlogP:
    1.12

    Polar Surface Area:
    148.46

    HBA:
    9

    HBD:
    4

    #RO5 Violations:
    0

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.43

    DETAILS
  5. Tetrahydrouridine
    ALA1863677

    Name:
    SID99355885

    Mol. Formula:
    C23H24N4O8S

    M.W.:
    516.53

    Type:
    Small molecule

    AlogP:
    0.20

    Polar Surface Area:
    153.08

    HBA:
    10

    HBD:
    2

    #RO5 Violations:
    1

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.49

    DETAILS
  6. Tetrahydrouridine
    ALA1863728

    Name:
    SID47196140

    Mol. Formula:
    C8H11N3OS

    M.W.:
    197.26

    Type:
    Small molecule

    AlogP:
    1.67

    Polar Surface Area:
    54.88

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.78

    DETAILS
  7. Tetrahydrouridine
    ALA1863978

    Name:
    SID85269337

    Mol. Formula:
    C17H13FN2O5

    M.W.:
    344.30

    Type:
    Small molecule

    AlogP:
    2.14

    Polar Surface Area:
    101.57

    HBA:
    5

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.64

    DETAILS
  8. Tetrahydrouridine
    ALA1864015

    Name:
    SID99360895

    Mol. Formula:
    C17H15N3O3S

    M.W.:
    341.39

    Type:
    Small molecule

    AlogP:
    4.12

    Polar Surface Area:
    80.32

    HBA:
    5

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.70

    DETAILS
  9. Tetrahydrouridine
    ALA1864091

    Name:
    SID47195430

    Mol. Formula:
    C16H12N2O2

    M.W.:
    264.28

    Type:
    Small molecule

    AlogP:
    3.64

    Polar Surface Area:
    55.24

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.78

    DETAILS
  10. Tetrahydrouridine
    ALA1864145

    Name:
    SID103163184

    Mol. Formula:
    C14H11NO7

    M.W.:
    305.24

    Type:
    Small molecule

    AlogP:
    2.24

    Polar Surface Area:
    108.88

    HBA:
    7

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.35

    DETAILS