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Lysine-specific demethylase 4A

Name And Classification

ID:  ALA5896

Type:  SINGLE PROTEIN

Synonyms:   1.14.11.66 | 1.14.11.69 | JHDM3A | JmjC domain-containing histone demethylation protein 3A | JMJD2 | JMJD2A | Jumonji domain-containing protein 2A | KDM4A | KIAA0677 | Lysine-specific demethylase 4A | [histone H3]-trimethyl-L-lysine(36) demethylase 4A | [histone H3]-trimethyl-L-lysine(9) demethylase 4A

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Epigenetic regulator / Eraser / Lysine demethylase / Jumonji domain-containing

Target Relations

ALA IDRelationshipPref NameTarget Type
ALA3430889SUBSET OFLysine-specific demethylase 4A/Lysine-specific demethylase 4BPROTEIN COMPLEX

Target Components

DescriptionRelationshipAccession
Lysine-specific demethylase 4APROTEINO75164

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelActivityView Details

Associated Active Ligands

  1. Tetrahydrouridine
    ALA10842

    Name:
    SID49645487

    Mol. Formula:
    C12H20N2O2

    M.W.:
    224.30

    Type:
    Small molecule

    AlogP:
    -0.08

    Polar Surface Area:
    43.78

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    Y

    QED Weighted:
    0.67

    DETAILS
  2. Tetrahydrouridine
    ALA28250

    Name:
    SID87335404

    Mol. Formula:
    C16H18O4

    M.W.:
    274.32

    Type:
    Small molecule

    AlogP:
    3.39

    Polar Surface Area:
    36.92

    HBA:
    4

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.84

    DETAILS
  3. Tetrahydrouridine
    ALA59827

    Name:
    SID92763394

    Mol. Formula:
    C10H12ClNO6

    M.W.:
    277.66

    Type:
    Small molecule

    AlogP:
    -1.18

    Polar Surface Area:
    112.15

    HBA:
    7

    HBD:
    4

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.54

    DETAILS
  4. Tetrahydrouridine
    ALA81698

    Name:
    SID87335721

    Mol. Formula:
    C18H10O6S

    M.W.:
    354.34

    Type:
    Small molecule

    AlogP:
    3.46

    Polar Surface Area:
    100.88

    HBA:
    7

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.57

    DETAILS
  5. Tetrahydrouridine
    ALA328834

    Name:
    SID92763418

    Mol. Formula:
    C12H15N5O5

    M.W.:
    309.28

    Type:
    Small molecule

    AlogP:
    -2.28

    Polar Surface Area:
    169.74

    HBA:
    9

    HBD:
    5

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.42

    DETAILS
  6. Tetrahydrouridine
    ALA251339

    Name:
    SID49645700

    Mol. Formula:
    C20H15NO5S

    M.W.:
    381.41

    Type:
    Small molecule

    AlogP:
    2.90

    Polar Surface Area:
    93.45

    HBA:
    5

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.59

    DETAILS
  7. Tetrahydrouridine
    ALA399899

    Name:
    SID49645629

    Mol. Formula:
    C22H17NO4S

    M.W.:
    391.45

    Type:
    Small molecule

    AlogP:
    3.04

    Polar Surface Area:
    80.31

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.58

    DETAILS
  8. Tetrahydrouridine
    ALA551319

    Name:
    2-((carboxymethyl)(3-(dimethylamino)benzyl)amino)-2-oxoacetic acid

    Mol. Formula:
    C13H16N2O5

    M.W.:
    280.28

    Type:
    Small molecule

    AlogP:
    0.25

    Polar Surface Area:
    98.15

    HBA:
    4

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.75

    DETAILS
  9. Tetrahydrouridine
    ALA556335

    Name:
    2-((carboxymethyl)(3-(4-(dimethylamino)phenyl)propyl)amino)-2-oxoacetic acid

    Mol. Formula:
    C15H20N2O5

    M.W.:
    308.33

    Type:
    Small molecule

    AlogP:
    0.68

    Polar Surface Area:
    98.15

    HBA:
    4

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.72

    DETAILS
  10. Tetrahydrouridine
    ALA1188270

    Name:
    4-(pyridin-3-yl)thiazol-2-amine

    Mol. Formula:
    C8H7N3S

    M.W.:
    177.23

    Type:
    Small molecule

    AlogP:
    1.79

    Polar Surface Area:
    51.80

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    1

    Passes Ro3:
    N

    QED Weighted:
    0.72

    DETAILS