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LLC-PK1

Name And Classification

ID:  ALA614577

Type:  CELL-LINE

Organism:  Sus scrofa

Species Group:  Sus scrofa

Name:  LLC-PK1

Description:  LLC-PK1 (Renal epithelial cells)

Source tissue:  Renal epithelial cells

Source Organism:  Sus scrofa

Source Tax ID:  9823

Cell Line Ontology:  CLO_0007331

Cellosaurus:  CVCL_0391

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelActivityView Details

Associated Active Ligands

  1. Tetrahydrouridine
    ALA404194

    Name:
    (3,4-dimethoxyphenyl)((3R,4R,5S)-5-(3-hydroxy-5-methoxyphenyl)-4-(hydroxymethyl)-tetrahydrofuran-3-yl)methanone

    Mol. Formula:
    C21H24O7

    M.W.:
    388.42

    Type:
    Small molecule

    AlogP:
    2.60

    Polar Surface Area:
    94.45

    HBA:
    7

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.70

    DETAILS
  2. Tetrahydrouridine
    ALA257069

    Name:
    (4-hydroxy-3-methoxyphenyl)((3R,4R,5S)-5-(3-hydroxy-5-methoxyphenyl)-4-(hydroxymethyl)-tetrahydrofuran-3-yl)methanone

    Mol. Formula:
    C20H22O7

    M.W.:
    374.39

    Type:
    Small molecule

    AlogP:
    2.29

    Polar Surface Area:
    105.45

    HBA:
    7

    HBD:
    3

    #RO5 Violations:
    0

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.67

    DETAILS
  3. Tetrahydrouridine
    ALA1834226

    Name:
    rac-N'-(3-Chlorophenylsulfonyl)-N,4-diethyl-4,5-dihydro-1Hpyrazole-1-carboxamidine

    Mol. Formula:
    C14H19ClN4O2S

    M.W.:
    342.85

    Type:
    Small molecule

    AlogP:
    2.32

    Polar Surface Area:
    74.13

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.67

    DETAILS
  4. Tetrahydrouridine
    ALA1834234

    Name:
    rac-N'-(3-Chlorophenylsulfonyl)-N-ethyl-5-phenyl-4,5-dihydro-1H-pyrazole-1-carboxamidine

    Mol. Formula:
    C18H19ClN4O2S

    M.W.:
    390.90

    Type:
    Small molecule

    AlogP:
    3.43

    Polar Surface Area:
    74.13

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.64

    DETAILS
  5. Tetrahydrouridine
    ALA1939357

    Name:
    (3S,5R,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-(6-methylhepta-1,5-dien-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol

    Mol. Formula:
    C30H50O2

    M.W.:
    442.73

    Type:
    Small molecule

    AlogP:
    7.31

    Polar Surface Area:
    40.46

    HBA:
    2

    HBD:
    2

    #RO5 Violations:
    1

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.45

    DETAILS
  6. Tetrahydrouridine
    ALA1939358

    Name:
    (3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-(6-methylhepta-1,5-dien-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthrene-3,6,12-triol

    Mol. Formula:
    C30H50O3

    M.W.:
    458.73

    Type:
    Small molecule

    AlogP:
    6.28

    Polar Surface Area:
    60.69

    HBA:
    3

    HBD:
    3

    #RO5 Violations:
    1

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.43

    DETAILS
  7. Tetrahydrouridine
    ALA1939359

    Name:
    (3S,5R,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-(6-methylhepta-2,5-dien-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol

    Mol. Formula:
    C30H50O2

    M.W.:
    442.73

    Type:
    Small molecule

    AlogP:
    7.31

    Polar Surface Area:
    40.46

    HBA:
    2

    HBD:
    2

    #RO5 Violations:
    1

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.45

    DETAILS
  8. Tetrahydrouridine
    ALA1939360

    Name:
    (3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-(6-methylhepta-2,5-dien-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthrene-3,6,12-triol

    Mol. Formula:
    C30H50O3

    M.W.:
    458.73

    Type:
    Small molecule

    AlogP:
    6.28

    Polar Surface Area:
    60.69

    HBA:
    3

    HBD:
    3

    #RO5 Violations:
    1

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.44

    DETAILS
  9. Tetrahydrouridine
    ALA2096845

    Name:
    3,3'-difluoro-4'-((S)-1-{[1-(3,3,3-trifluoro-propionylamino)-cyclopropanecarbonyl]-amino}-ethyl)-biphenyl-2-carboxylic acid methyl ester

    Mol. Formula:
    C23H21F5N2O4

    M.W.:
    484.42

    Type:
    Small molecule

    AlogP:
    4.20

    Polar Surface Area:
    84.50

    HBA:
    4

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.46

    DETAILS
  10. Tetrahydrouridine
    ALA2171303

    Name:
    5-fluoro-N-((2S,3R)-1-(4-fluorophenyl)-3-hydroxy-4-((S)-6'-neopentyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridine]-4'-ylamino)butan-2-yl)nicotinamide

    Mol. Formula:
    C32H38F2N4O3

    M.W.:
    564.68

    Type:
    Small molecule

    AlogP:
    5.08

    Polar Surface Area:
    96.37

    HBA:
    6

    HBD:
    3

    #RO5 Violations:
    2

    #Rotatable Bonds:
    9

    Passes Ro3:
    N

    QED Weighted:
    0.34

    DETAILS