| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA1774353 | 13a | INH | = | 15 | % | ALA1777177 | % | Mus musculus | |||
| 2. | ALA1774353 | 13a | INH | 0 | ALA1777176 | Dose-dependent effect | % | Mus musculus | ||||
| 3. | ALA1774353 | 13a | INH | 0 | ALA1777174 | Dose-dependent effect | % | Mus musculus | ||||
| 4. | ALA1774353 | 13a | INH | = | 15 | % | ALA1777175 | % | Mus musculus | |||
| 5. | ALA1774353 | 13a | PPB | = | 95 | % | ALA1777173 | % | Mus musculus | |||
| 6. | ALA1774353 | 13a | PPB | = | 92 | % | ALA1777172 | % | Rattus norvegicus | |||
| 7. | ALA1774353 | 13a | PPB | = | 86 | % | ALA1777171 | % | Homo sapiens | |||
| 8. | ALA1774353 | 13a | F | = | 140 | % | ALA1777170 | % | Mus musculus | |||
| 9. | ALA1774353 | 13a | AUC | = | 6.1 | uM.hr | ALA1777169 | standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | ng.hr.mL-1 | Mus musculus | ||
| 10. | ALA1774353 | 13a | t1/2 | = | 0.4 | hr | ALA1777168 | hr | Mus musculus | |||
| 11. | ALA1774353 | 13a | Vdss | = | 1.4 | L/Kg | ALA1777167 | L.kg-1 | Mus musculus | |||
| 12. | ALA1774353 | 13a | CL | = | 46 | ml/min.kg | ALA1777160 | mL.min-1.kg-1 | Mus musculus | |||
| 13. | ALA1774353 | 13a | IC50 | = | 52 | nM | ALA1777161 | 7.28 | nM | Homo sapiens | ||
| 14. | ALA1774353 | 13a | IC50 | = | 78 | nM | ALA1777162 | 7.11 | nM | Homo sapiens | ||
| 15. | ALA1774353 | 13a | IC50 | = | 13 | nM | ALA1777163 | 7.89 | nM | Homo sapiens | ||
| 16. | ALA1774353 | 13a | IC50 | = | 4.6 | nM | ALA1777165 | 8.34 | nM | Homo sapiens | ||
| 17. | ALA1774353 | 13a | Ratio Ki | = | 290 | ALA1777164 | ||||||
| 18. | ALA1774353 | 13a | Ratio Ki | = | 120 | ALA1777166 | ||||||
| 19. | ALA1774353 | 13a | Ki | = | 1.4 | nM | ALA1777159 | 8.85 | nM | Homo sapiens |
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