| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA1778639 | 34 | CLint | < | 3 | microL/min/mg | ALA3301370 | mL.min-1.g-1 | ||||
| 2. | ALA1778639 | 34 | CLint | < | 3 | microL/min/1E6 cells | ALA3301372 | uL.min-1.(10^6cells)-1 | ||||
| 3. | ALA1778639 | 34 | pKa_A1 | 3.2 | ALA3301375 | "A1 Functional Group: Carboxylic acid; Ionisation Formula: A1B0 (Functional Group: the part of the molecule the pKa refers to; Ionisation formula: AxBy where 'A' refers to acidic centers within the molecule that are appreciably ionised at a pH <= 11 and 'x' equals 0, 1 or 2; and 'B' refers to basic centers within the molecule that are appreciably ionised at a pH >= 2 and 'y' equals 0, 1, 2 or 3)." | ||||||
| 4. | ALA1778639 | 34 | LogD7.4 | -0.45 | ALA3301363 | |||||||
| 5. | ALA1778639 | 34 | PPB | 97 | % | ALA3301367 | % | |||||
| 6. | ALA1778639 | 34 | PPB | 95.72 | % | ALA3301365 | % | |||||
| 7. | ALA1778639 | 34 | PPB | 92.95 | % | ALA3301366 | % | |||||
| 8. | ALA1778639 | 34 | PPB | 90.72 | % | ALA3301369 | % | |||||
| 9. | ALA1778639 | 34 | PPB | 79.17 | % | ALA3301368 | % | |||||
| 10. | ALA1778639 | 34 | F | = | 42 | % | ALA1780698 | % | Rattus norvegicus | |||
| 11. | ALA1778639 | 34 | t1/2 | = | 1.1 | hr | ALA1780697 | hr | Rattus norvegicus | |||
| 12. | ALA1778639 | 34 | logD | = | 0.5 | ALA1780748 | ||||||
| 13. | ALA1778639 | 34 | Activity | 0 | ALA1780747 | Active | Mus musculus | |||||
| 14. | ALA1778639 | 34 | Intrinsic activity | <= | 0.1 | ALA1780693 | Homo sapiens | |||||
| 15. | ALA1778639 | 34 | IC50 | = | 0.9 | nM | ALA1780687 | 9.05 | nM | Homo sapiens | ||
| 16. | ALA1778639 | 34 | CL | = | 4 | uL/min/10^6cells | ALA1780688 | uL.min-1.(10^6cells)-1 | Rattus norvegicus | |||
| 17. | ALA1778639 | 34 | CL | < | 3 | microL/min/mg | ALA1780689 | mL.min-1.g-1 | Homo sapiens | |||
| 18. | ALA1778639 | 34 | IC50 | = | 29 | nM | ALA1780695 | 7.54 | nM | Homo sapiens | ||
| 19. | ALA1778639 | 34 | Selectivity ratio | = | 1000 | ALA1780696 | ||||||
| 20. | ALA1778639 | 34 | Selectivity ratio | = | 1000 | ALA1780699 |
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