| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA1819090 | DSR-12727, 7a | NOAEL | = | 60 | mg/kg/day | ALA1821090 | mg/kg/day | Macaca mulatta | |||
| 2. | ALA1819090 | DSR-12727, 7a | NOAEL | = | 60 | mg/kg/day | ALA1821089 | mg/kg/day | Rattus norvegicus | |||
| 3. | ALA1819090 | DSR-12727, 7a | Activity | 0 | ALA1821088 | Non-toxic | Salmonella enterica subsp. enterica serovar Typhimurium | |||||
| 4. | ALA1819090 | DSR-12727, 7a | solubility | = | 1 | mg/ml | ALA1821087 | ug.mL-1 | ||||
| 5. | ALA1819090 | DSR-12727, 7a | Activity | 0 | ALA1821019 | Dose-dependent effect | Rattus norvegicus | |||||
| 6. | ALA1819090 | DSR-12727, 7a | AUC | = | 2167 | ng.hr/ml | ALA1821086 | ng.hr.mL-1 | Rattus norvegicus | |||
| 7. | ALA1819090 | DSR-12727, 7a | Cmax | = | 309 | ng/ml | ALA1821085 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | Rattus norvegicus | ||
| 8. | ALA1819090 | DSR-12727, 7a | INH | 0 | ALA1821084 | Active | % | Rattus norvegicus | ||||
| 9. | ALA1819090 | DSR-12727, 7a | PPB | = | 73 | % | ALA1821083 | % | Homo sapiens | |||
| 10. | ALA1819090 | DSR-12727, 7a | PPB | = | 69 | % | ALA1821082 | % | Macaca mulatta | |||
| 11. | ALA1819090 | DSR-12727, 7a | PPB | = | 59 | % | ALA1821081 | % | Canis lupus familiaris | |||
| 12. | ALA1819090 | DSR-12727, 7a | PPB | = | 78 | % | ALA1821080 | % | Rattus norvegicus | |||
| 13. | ALA1819090 | DSR-12727, 7a | F | = | 38 | % | ALA1821079 | % | Macaca mulatta | |||
| 14. | ALA1819090 | DSR-12727, 7a | t1/2 | = | 15 | hr | ALA1821078 | hr | Macaca mulatta | |||
| 15. | ALA1819090 | DSR-12727, 7a | Cmax | = | 77 | ng/ml | ALA1821077 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | Macaca mulatta | ||
| 16. | ALA1819090 | DSR-12727, 7a | t1/2 | = | 4.8 | hr | ALA1821076 | hr | Macaca mulatta | |||
| 17. | ALA1819090 | DSR-12727, 7a | Vdss | = | 10 | L/Kg | ALA1821075 | L.kg-1 | Macaca mulatta | |||
| 18. | ALA1819090 | DSR-12727, 7a | CL | = | 38 | ml/min.kg | ALA1821074 | mL.min-1.kg-1 | Macaca mulatta | |||
| 19. | ALA1819090 | DSR-12727, 7a | F | = | 91 | % | ALA1821073 | % | Canis lupus familiaris | |||
| 20. | ALA1819090 | DSR-12727, 7a | t1/2 | = | 3.9 | hr | ALA1821072 | hr | Canis lupus familiaris |
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