# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | ALA1829335 | 8a, CEP-26401, irdabisant | Ki | = | 2 | nM | ALA3123356 | 8.70 | nM | Homo sapiens | ||
2. | ALA1829335 | 8a, CEP-26401, irdabisant | Ki | = | 7.2 | nM | ALA3123355 | 8.14 | nM | Rattus norvegicus | ||
3. | ALA1829335 | 8a, CEP-26401, irdabisant | Ki | = | 2 | nM | ALA3421047 | 8.70 | nM | Homo sapiens | ||
4. | ALA1829335 | 8a, CEP-26401, irdabisant | Ki | = | 7.2 | nM | ALA3421048 | 8.14 | nM | Rattus norvegicus | ||
5. | ALA1829335 | 8a, CEP-26401, irdabisant | BPR | = | 2.6 | ALA1960234 | ||||||
6. | ALA1829335 | 8a, CEP-26401, irdabisant | F | = | 83 | % | ALA1960233 | % | Rattus norvegicus | |||
7. | ALA1829335 | 8a, CEP-26401, irdabisant | CL | = | 42 | ml/min.kg | ALA1960081 | mL.min-1.kg-1 | Rattus norvegicus | |||
8. | ALA1829335 | 8a, CEP-26401, irdabisant | t1/2 | = | 2.6 | hr | ALA1960082 | hr | Rattus norvegicus | |||
9. | ALA1829335 | 8a, CEP-26401, irdabisant | Ki | = | 8.5 | nM | ALA1960083 | 8.07 | nM | Rattus norvegicus | ||
10. | ALA1829335 | 8a, CEP-26401, irdabisant | Ki | = | 2 | nM | ALA1960084 | 8.70 | nM | Homo sapiens | ||
11. | ALA1829335 | 8a, CEP-26401, irdabisant | Ki | = | 7 | nM | ALA1919507 | 8.15 | nM | Rattus norvegicus | ||
12. | ALA1829335 | 8a, CEP-26401, irdabisant | Ki | = | 2 | nM | ALA1919506 | 8.70 | nM | Homo sapiens | ||
13. | ALA1829335 | 8a, CEP-26401, irdabisant | TI | > | 1000 | ALA1817087 | ||||||
14. | ALA1829335 | 8a, CEP-26401, irdabisant | Drug uptake | = | 36 | uM | ALA1817086 | uM | Rattus norvegicus | |||
15. | ALA1829335 | 8a, CEP-26401, irdabisant | Activity | 0 | ALA1817085 | Non-toxic | Rattus norvegicus | |||||
16. | ALA1829335 | 8a, CEP-26401, irdabisant | Activity | 0 | ALA1817084 | Non-toxic | Rattus norvegicus | |||||
17. | ALA1829335 | 8a, CEP-26401, irdabisant | ED50 | = | 0.01 | mg kg-1 | ALA1817083 | mg.kg-1 | Rattus norvegicus | |||
18. | ALA1829335 | 8a, CEP-26401, irdabisant | ED50 | = | 0.06 | mg kg-1 | ALA1817082 | mg.kg-1 | Rattus norvegicus | |||
19. | ALA1829335 | 8a, CEP-26401, irdabisant | IC50 | = | 17.5 | uM | ALA1816547 | 4.76 | nM | Homo sapiens | ||
20. | ALA1829335 | 8a, CEP-26401, irdabisant | IC50 | = | 9.4 | uM | ALA1816546 | 5.03 | nM | Homo sapiens |