# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | ALA1946956 | 42, BDM41906 | IC50 | = | 0.4 | uM | ALA4434519 | 6.40 | nM | Mycobacterium tuberculosis | ||
2. | ALA1946956 | 42, BDM41906 | Ratio | > | 30 | ALA1948070 | ||||||
3. | ALA1946956 | 42, BDM41906 | AUC | = | 98.6 | ug/ml.hr | ALA1947976 | ng.hr.mL-1 | Mus musculus | |||
4. | ALA1946956 | 42, BDM41906 | CLH | = | 15 | microL/min/mg | ALA1947971 | mL.min-1.g-1 | Mus musculus | |||
5. | ALA1946956 | 42, BDM41906 | t1/2 | = | 81 | min | ALA1947970 | hr | Mus musculus | |||
6. | ALA1946956 | 42, BDM41906 | solubility | = | 410 | ug ml-1 | ALA1947972 | ug.mL-1 | ||||
7. | ALA1946956 | 42, BDM41906 | INH | 0 | ALA1947973 | Dose-dependent effect | % | Mycobacterium tuberculosis | ||||
8. | ALA1946956 | 42, BDM41906 | IC50 | = | 0.4 | uM | ALA1947973 | 6.40 | nM | Mycobacterium tuberculosis | ||
9. | ALA1946956 | 42, BDM41906 | EC50 | = | 0.06 | uM | ALA1947974 | 7.22 | nM | Mycobacterium tuberculosis | ||
10. | ALA1946956 | 42, BDM41906 | CC50 | > | 20 | uM | ALA4296191 | Median N= 2; Maxinhib 22.4 Pct | nM | Homo sapiens | ||
11. | ALA1946956 | 42, BDM41906 | HC10 | > | 20 | uM | ALA4296784 | Median N= 2; Maxinhib 13.9 Pct | uM | |||
12. | ALA1946956 | 42, BDM41906 | MIC | > | 20 | uM | ALA4296184 | Median N= 2; Maxinhib 10.8 Pct | nM | Staphylococcus aureus | ||
13. | ALA1946956 | 42, BDM41906 | MIC | > | 20 | uM | ALA4296802 | Median N= 2; Maxinhib 5.2 Pct | nM | Pseudomonas aeruginosa | ||
14. | ALA1946956 | 42, BDM41906 | MIC | > | 20 | uM | ALA4296188 | Median N= 2; Maxinhib 15.6 Pct | nM | Acinetobacter baumannii | ||
15. | ALA1946956 | 42, BDM41906 | MIC | > | 20 | uM | ALA4296187 | Median N= 2; Maxinhib 19.4 Pct | nM | Pseudomonas aeruginosa | ||
16. | ALA1946956 | 42, BDM41906 | MIC | > | 20 | uM | ALA4296186 | Median N= 2; Maxinhib 15.3 Pct | nM | Klebsiella pneumoniae | ||
17. | ALA1946956 | 42, BDM41906 | MIC | > | 20 | uM | ALA4296185 | Median N= 2; Maxinhib 4.2 Pct | nM | Escherichia coli | ||
18. | ALA1946956 | 42, BDM41906 | MIC | > | 20 | uM | ALA4296190 | Median N= 2; Maxinhib 6.8 Pct | nM | Cryptococcus neoformans | ||
19. | ALA1946956 | 42, BDM41906 | MIC | > | 20 | uM | ALA4296189 | Median N= 2; Maxinhib 3.9 Pct | nM | Candida albicans |