# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | Lifitegrast | 1g, SAR 1118 | INH | 0 | ALA2051141 | Active | % | Homo sapiens | ||||
2. | Lifitegrast | 1g, SAR 1118 | INH | 0 | ALA2051140 | Active | % | Homo sapiens | ||||
3. | Lifitegrast | 1g, SAR 1118 | INH | 0 | ALA2051139 | Active | % | Homo sapiens | ||||
4. | Lifitegrast | 1g, SAR 1118 | INH | 0 | ALA2051138 | Active | % | Homo sapiens | ||||
5. | Lifitegrast | 1g, SAR 1118 | INH | 0 | ALA2051034 | Active | % | Homo sapiens | ||||
6. | Lifitegrast | 1g, SAR 1118 | INH | 0 | ALA2051033 | Active | % | Homo sapiens | ||||
7. | Lifitegrast | 1g, SAR 1118 | Activity | = | 3.4 | mm | ALA2051032 | mm | Canis lupus familiaris | |||
8. | Lifitegrast | 1g, SAR 1118 | Activity | 0 | ALA2051031 | Toxic | Canis lupus familiaris | |||||
9. | Lifitegrast | 1g, SAR 1118 | IC50 | > | 20 | uM | ALA2051023 | nM | Homo sapiens | |||
10. | Lifitegrast | 1g, SAR 1118 | IC50 | = | 3 | uM | ALA2051022 | 5.52 | nM | Homo sapiens | ||
11. | Lifitegrast | 1g, SAR 1118 | IC50 | > | 20 | uM | ALA2051021 | nM | Homo sapiens | |||
12. | Lifitegrast | 1g, SAR 1118 | Activity | 0 | ALA2051020 | Non-toxic | Salmonella enterica subsp. enterica serovar Typhimurium | |||||
13. | Lifitegrast | 1g, SAR 1118 | IC50 | = | 2.98 | nM | ALA2051019 | 8.53 | nM | Homo sapiens | ||
14. | Lifitegrast | 1g, SAR 1118 | AUC | = | 705 | ng.hr/Kg | ALA2051018 | ng.hr/Kg | Rattus norvegicus | |||
15. | Lifitegrast | 1g, SAR 1118 | CL | = | 139.2 | ml/min.kg | ALA2051017 | mL.min-1.kg-1 | Rattus norvegicus | |||
16. | Lifitegrast | 1g, SAR 1118 | t1/2 | = | 0.78 | hr | ALA2051016 | hr | Rattus norvegicus | |||
17. | Lifitegrast | 1g, SAR 1118 | Stability | > | 95 | % | ALA2051015 | % | Rattus norvegicus | |||
18. | Lifitegrast | 1g, SAR 1118 | Stability | = | 71 | % | ALA2051014 | % | Homo sapiens | |||
19. | Lifitegrast | 1g, SAR 1118 | IC50 | = | 0.074 | uM | ALA2051013 | 7.13 | nM | Homo sapiens | ||
20. | Lifitegrast | 1g, SAR 1118 | IC50 | = | 0.009 | uM | ALA2051012 | 8.05 | nM | Homo sapiens |