# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | ALA2059435 | 29, AM-8553 | CLH | = | 21 | uL/min | ALA3363509 | uL/min | ||||
2. | ALA2059435 | 29, AM-8553 | IC50 | = | 0.073 | uM | ALA3363507 | 7.14 | nM | Homo sapiens | ||
3. | ALA2059435 | 29, AM-8553 | IC50 | = | 0.001 | uM | ALA3363505 | 9.00 | nM | Homo sapiens | ||
4. | ALA2059435 | 29, AM-8553 | IC50 | = | 0.006 | uM | ALA3363506 | 8.22 | nM | Homo sapiens | ||
5. | ALA2059435 | 29, AM-8553 | IC50 | = | 1 | nM | ALA3888180 | 9.00 | 378580 | nM | Homo sapiens | |
6. | ALA2059435 | 29, AM-8553 | IC50 | = | 10 | nM | ALA3888179 | 8.00 | 378478 | nM | Homo sapiens | |
7. | ALA2059435 | 29, AM-8553 | IC50 | = | 1.1 | nM | ALA2182642 | 8.96 | nM | Homo sapiens | ||
8. | ALA2059435 | 29, AM-8553 | IC50 | = | 4.2 | nM | ALA2182643 | 8.38 | nM | Homo sapiens | ||
9. | ALA2059435 | 29, AM-8553 | IC50 | = | 0.76 | uM | ALA2182644 | 6.12 | nM | Homo sapiens | ||
10. | ALA2059435 | 29, AM-8553 | IC50 | = | 0.068 | uM | ALA2182645 | 7.17 | nM | Homo sapiens | ||
11. | ALA2059435 | 29, AM-8553 | IC50 | = | 0.2 | uM | ALA2182646 | 6.70 | nM | Homo sapiens | ||
12. | ALA2059435 | 29, AM-8553 | IC50 | > | 25 | uM | ALA2182647 | nM | Homo sapiens | |||
13. | ALA2059435 | 29, AM-8553 | Kd | = | 0.4 | nM | ALA2182652 | 9.40 | nM | Homo sapiens | ||
14. | ALA2059435 | 29, AM-8553 | Activity | = | 15 | % | ALA2182653 | % | Homo sapiens | |||
15. | ALA2059435 | 29, AM-8553 | INH | = | 13 | % | ALA2182654 | % | Homo sapiens | |||
16. | ALA2059435 | 29, AM-8553 | Activity | = | 96 | % | ALA2182655 | % | Homo sapiens | |||
17. | ALA2059435 | 29, AM-8553 | CLH | = | 0.72 | L/hr/kg | ALA2182656 | mL.min-1.kg-1 | Macaca fascicularis | |||
18. | ALA2059435 | 29, AM-8553 | Vd | = | 6.2 | L/Kg | ALA2182657 | L.kg-1 | Macaca fascicularis | |||
19. | ALA2059435 | 29, AM-8553 | t1/2 | = | 14 | hr | ALA2182658 | hr | Macaca fascicularis | |||
20. | ALA2059435 | 29, AM-8553 | Activity | 0 | ALA2182660 | Dose-dependent effect | Mus musculus |