# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | ALA2094282 | DNDI1317463 | IC50 | = | 0.22 | uM | ALA2411136 | 6.66 | nM | Trypanosoma brucei brucei | ||
2. | ALA2094282 | DNDI1317463 | IC50 | = | 0.59 | uM | ALA2411135 | 6.23 | nM | Trypanosoma brucei rhodesiense | ||
3. | ALA2094282 | DNDI1317463 | IC50 | = | 0.23 | uM | ALA2411133 | 6.64 | nM | Trypanosoma cruzi | ||
4. | ALA2094282 | DNDI1317463 | IC50 | = | 7.8 | uM | ALA2411130 | 5.11 | nM | Plasmodium falciparum | ||
5. | ALA2094282 | DNDI1317463 | IC50 | = | 1.8 | uM | ALA2411129 | 5.75 | nM | Leishmania donovani | ||
6. | ALA2094282 | DNDI1317463 | IC50 | = | 23 | uM | ALA2411127 | 4.64 | nM | Rattus norvegicus | ||
7. | ALA2094282 | DNDI1317463 | logD | = | 2.7 | ALA2411125 | ||||||
8. | ALA2094282 | DNDI1317463 | Kinetic_solubility | = | 1.6 | ug ml-1 | ALA2411126 | ug.mL-1 | ||||
9. | ALA2094282 | DNDI1317463 | Kinetic_solubility | = | 1.6 | ug ml-1 | ALA2411123 | ug.mL-1 | ||||
10. | ALA2094282 | DNDI1317463 | t1/2 | = | 7 | min | ALA2411124 | hr | Homo sapiens | |||
11. | ALA2094282 | DNDI1317463 | CLH | = | 258 | microL/min/mg | ALA2411122 | mL.min-1.g-1 | Homo sapiens | |||
12. | ALA2094282 | DNDI1317463 | Ratio IC50 | > | 345 | ALA2411134 | ||||||
13. | ALA2094282 | DNDI1317463 | Ratio IC50 | = | 39 | ALA2411132 | ||||||
14. | ALA2094282 | DNDI1317463 | Ratio IC50 | = | 99 | ALA2411131 | ||||||
15. | ALA2094282 | DNDI1317463 | IC50 | = | 0.17 | uM | ALA2095144 | 6.77 | nM | Trypanosoma brucei brucei | ||
16. | ALA2094282 | DNDI1317463 | IC50 | > | 41.67 | uM | ALA2095143 | nM | Homo sapiens | |||
17. | ALA2094282 | DNDI1317463 | CC50 | > | 50 | uM | ALA4481165 | nM | Mus musculus | |||
18. | ALA2094282 | DNDI1317463 | F | < | 5 | % | ALA4481166 | % | ||||
19. | ALA2094282 | DNDI1317463 | EC50 | = | 7.3 | uM | ALA4481161 | 5.14 | nM | Leishmania donovani | ||
20. | ALA2094282 | DNDI1317463 | CC50 | = | 17 | uM | ALA4481164 | nM | Mus musculus |