Activities

#	Name	Compound Key	Action Type	Relation	Activity Value	Units	Assay ID	Assay Description	Comment	Assay	Assay Organism
1.	N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide	5g	PPB		99.91	%	ALA3301365			%
2.	N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide	5g	PPB		98.81	%	ALA3301366			%
3.	N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide	5g	CLint		19.95	microL/min/1E6 cells	ALA3301372			uL.min-1.(10^6cells)-1
4.	N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide	5g	IC50	=	135	nM	ALA2155423	6.87		nM	Rattus norvegicus
5.	N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide	5g	F	=	26	%	ALA2155517			%	Rattus norvegicus
6.	N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide	5g	beta t1/2	=	0.9	hr	ALA2155516			hr	Rattus norvegicus
7.	N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide	5g	AUC	=	69	uM.hr	ALA2155515		standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW \| standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW \| standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW \| standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW \| standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW \| standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW	ng.hr.mL-1	Rattus norvegicus
8.	N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide	5g	Cp	=	2.6	uM	ALA2155514			uM	Rattus norvegicus
9.	N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide	5g	Cp	=	11.3	uM	ALA2155513			uM	Rattus norvegicus
10.	N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide	5g	Tmax	=	0.5	hr	ALA2155512			hr	Rattus norvegicus
11.	N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide	5g	Cmax	=	37	uM	ALA2155511			nM	Rattus norvegicus
12.	N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide	5g	Cp	=	19	uM	ALA2155434			uM	Rattus norvegicus
13.	N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide	5g	Cp	=	19	uM	ALA2155433			uM	Rattus norvegicus
14.	N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide	5g	Cp	=	22	uM	ALA2155432			uM	Rattus norvegicus
15.	N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide	5g	AUC	=	267	uM.hr	ALA2155431		standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW \| standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW \| standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW \| standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW \| standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW \| standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW	ng.hr.mL-1	Rattus norvegicus
16.	N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide	5g	Tmax	=	2	hr	ALA2155430			hr	Rattus norvegicus
17.	N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide	5g	Cmax	=	22	uM	ALA2155429			nM	Rattus norvegicus
18.	N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide	5g	beta t1/2	=	1.1	hr	ALA2155428			hr	Rattus norvegicus
19.	N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide	5g	Vdss	=	0.36	L/Kg	ALA2155427			L.kg-1	Rattus norvegicus
20.	N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide	5g	CL	=	4.7	ml/min.kg	ALA2155426			mL.min-1.kg-1	Rattus norvegicus

1.

N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide

5g

PPB

99.91

%

ALA3301365

%

2.

N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide

5g

PPB

98.81

%

ALA3301366

%

3.

N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide

5g

CLint

19.95

microL/min/1E6 cells

ALA3301372

uL.min-1.(10^6cells)-1

4.

N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide

5g

IC50

=

135

nM

ALA2155423

6.87

nM

Rattus norvegicus

5.

N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide

5g

F

=

26

%

ALA2155517

%

Rattus norvegicus

6.

N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide

5g

beta t1/2

=

0.9

hr

ALA2155516

hr

Rattus norvegicus

7.

N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide

5g

AUC

=

69

uM.hr

ALA2155515

standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW

ng.hr.mL-1

Rattus norvegicus

8.

N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide

5g

Cp

=

2.6

uM

ALA2155514

uM

Rattus norvegicus

9.

N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide

5g

Cp

=

11.3

uM

ALA2155513

uM

Rattus norvegicus

10.

N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide

5g

Tmax

=

0.5

hr

ALA2155512

hr

Rattus norvegicus

11.

N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide

5g

Cmax

=

37

uM

ALA2155511

nM

Rattus norvegicus

12.

N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide

5g

Cp

=

19

uM

ALA2155434

uM

Rattus norvegicus

13.

N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide

5g

Cp

=

19

uM

ALA2155433

uM

Rattus norvegicus

14.

N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide

5g

Cp

=

22

uM

ALA2155432

uM

Rattus norvegicus

15.

N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide

5g

AUC

=

267

uM.hr

ALA2155431

standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW

ng.hr.mL-1

Rattus norvegicus

16.

N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide

5g

Tmax

=

2

hr

ALA2155430

hr

Rattus norvegicus

17.

N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide

5g

Cmax

=

22

uM

ALA2155429

nM

Rattus norvegicus

18.

N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide

5g

beta t1/2

=

1.1

hr

ALA2155428

hr

Rattus norvegicus

19.

N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide

5g

Vdss

=

0.36

L/Kg

ALA2155427

L.kg-1

Rattus norvegicus

20.

N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide

5g

CL

=

4.7

ml/min.kg

ALA2155426

mL.min-1.kg-1

Rattus norvegicus