Activities

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Activities

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#	Name	Compound Key	Action Type	Relation	Activity Value	Units	Assay ID	Assay Description	Comment	Assay	Assay Organism
1.	ALA2163587	34, AZD-4996	IC50	<	0.001	uM	ALA2175127			nM	Homo sapiens
2.	ALA2163587	34, AZD-4996	IC50	=	0.032	uM	ALA2174685	7.50		nM
3.	ALA2163587	34, AZD-4996	IC50	<	0.001	uM	ALA2168708			nM	Homo sapiens
4.	ALA2163587	34, AZD-4996	IC50		0		ALA2168709		Not Active		Homo sapiens
5.	ALA2163587	34, AZD-4996	IC50	>	4	uM	ALA2168710			nM	Homo sapiens
6.	ALA2163587	34, AZD-4996	IC50	>	2.9	uM	ALA2168711			nM	Homo sapiens
7.	ALA2163587	34, AZD-4996	logD	=	2.7		ALA2168713
8.	ALA2163587	34, AZD-4996	solubility	=	620	uM	ALA2168929			nM
9.	ALA2163587	34, AZD-4996	CLH	=	16	microL/min/mg	ALA2168927			mL.min-1.g-1	Homo sapiens
10.	ALA2163587	34, AZD-4996	CLH	=	67	microL/min/mg	ALA2168931			mL.min-1.g-1	Rattus norvegicus
11.	ALA2163587	34, AZD-4996	Fu	=	17	%	ALA2168930				Rattus norvegicus
12.	ALA2163587	34, AZD-4996	Fu	=	22	%	ALA2168928				Canis lupus familiaris
13.	ALA2163587	34, AZD-4996	CLH	=	2.5	uL/min	ALA2168714			uL/min
14.	ALA2163587	34, AZD-4996	CL	=	53	ml/min.kg	ALA2168715			mL.min-1.kg-1	Rattus norvegicus
15.	ALA2163587	34, AZD-4996	CL	=	10	ml/min.kg	ALA2168716			mL.min-1.kg-1	Canis lupus familiaris
16.	ALA2163587	34, AZD-4996	Vdss	=	2.3	L/Kg	ALA2168717			L.kg-1	Rattus norvegicus
17.	ALA2163587	34, AZD-4996	Vdss	=	1.7	L/Kg	ALA2168917			L.kg-1	Canis lupus familiaris
18.	ALA2163587	34, AZD-4996	t1/2	=	1	hr	ALA2168918			hr	Rattus norvegicus
19.	ALA2163587	34, AZD-4996	t1/2	=	1.5	hr	ALA2168919			hr	Canis lupus familiaris
20.	ALA2163587	34, AZD-4996	F	=	28	%	ALA2168920			%	Rattus norvegicus