Activities

#	Name	Compound Key	Action Type	Relation	Activity Value	Units	Assay ID	Assay Description	Comment	Assay	Assay Organism
1.	2'，3'-Didehydro-2'，3'-dideoxyuridine	2d	t1/2	=	15	hr	ALA5247120			hr
2.	2'，3'-Didehydro-2'，3'-dideoxyuridine	2d	EC50	>	100	uM	ALA1250634			nM	Plasmodium falciparum
3.	2'，3'-Didehydro-2'，3'-dideoxyuridine	2d	GI	=	0	%	ALA1250633			%	Plasmodium falciparum
4.	2'，3'-Didehydro-2'，3'-dideoxyuridine	2d	CC50	=	207	uM	ALA896312			nM
5.	2'，3'-Didehydro-2'，3'-dideoxyuridine	2d	EC50	>	50	uM	ALA896311			nM	Human immunodeficiency virus 2
6.	2'，3'-Didehydro-2'，3'-dideoxyuridine	2d	EC50	>	50	uM	ALA896310			nM	Human immunodeficiency virus 1
7.	2'，3'-Didehydro-2'，3'-dideoxyuridine	2d	IC50		0	uM	ALA883227		Not Determined	nM	Rattus norvegicus
8.	2'，3'-Didehydro-2'，3'-dideoxyuridine	2d	IC50	=	170	uM	ALA883226			nM	Trypanosoma cruzi
9.	2'，3'-Didehydro-2'，3'-dideoxyuridine	2d	IC50	=	72	uM	ALA883222	4.14		nM	Trypanosoma brucei rhodesiense
10.	2'，3'-Didehydro-2'，3'-dideoxyuridine	2d	IC50		0		ALA883232		Not Determined		Leishmania donovani
11.	2'，3'-Didehydro-2'，3'-dideoxyuridine	2d	IC50	=	214	uM	ALA885085			nM	Plasmodium falciparum
12.	2'，3'-Didehydro-2'，3'-dideoxyuridine	2d	SI	>	3		ALA883676				Plasmodium falciparum 3D7
13.	2'，3'-Didehydro-2'，3'-dideoxyuridine	2d	Ki	>	1	mM	ALA881474			nM	Homo sapiens
14.	2'，3'-Didehydro-2'，3'-dideoxyuridine	2d	Ki	>	1	mM	ALA884808			nM	Leishmania major
15.	2'，3'-Didehydro-2'，3'-dideoxyuridine	2d	Ki	=	298	uM	ALA885372			nM	Plasmodium falciparum 3D7
16.	2'，3'-Didehydro-2'，3'-dideoxyuridine	2d	IC50	>	100	uM	ALA757804			nM
17.	2'，3'-Didehydro-2'，3'-dideoxyuridine	2d	EC50	=	68.3	uM	ALA758934	4.17		nM
18.	2'，3'-Didehydro-2'，3'-dideoxyuridine	2d	Selectivity index	<	2		ALA841097				Homo sapiens
19.	2'，3'-Didehydro-2'，3'-dideoxyuridine	2d	CD50	=	39	uM	ALA712756			uM	Homo sapiens
20.	2'，3'-Didehydro-2'，3'-dideoxyuridine	2d	ED50	>	20	uM	ALA706937			uM	Human immunodeficiency virus 1

1.

2'，3'-Didehydro-2'，3'-dideoxyuridine

2d

t1/2

=

15

hr

ALA5247120

hr

2.

2'，3'-Didehydro-2'，3'-dideoxyuridine

2d

EC50

>

100

uM

ALA1250634

nM

Plasmodium falciparum

3.

2'，3'-Didehydro-2'，3'-dideoxyuridine

2d

GI

=

0

%

ALA1250633

%

Plasmodium falciparum

4.

2'，3'-Didehydro-2'，3'-dideoxyuridine

2d

CC50

=

207

uM

ALA896312

nM

5.

2'，3'-Didehydro-2'，3'-dideoxyuridine

2d

EC50

>

50

uM

ALA896311

nM

Human immunodeficiency virus 2

6.

2'，3'-Didehydro-2'，3'-dideoxyuridine

2d

EC50

>

50

uM

ALA896310

nM

Human immunodeficiency virus 1

7.

2'，3'-Didehydro-2'，3'-dideoxyuridine

2d

IC50

0

uM

ALA883227

Not Determined

nM

Rattus norvegicus

8.

2'，3'-Didehydro-2'，3'-dideoxyuridine

2d

IC50

=

170

uM

ALA883226

nM

Trypanosoma cruzi

9.

2'，3'-Didehydro-2'，3'-dideoxyuridine

2d

IC50

=

72

uM

ALA883222

4.14

nM

Trypanosoma brucei rhodesiense

10.

2'，3'-Didehydro-2'，3'-dideoxyuridine

2d

IC50

0

ALA883232

Not Determined

Leishmania donovani

11.

2'，3'-Didehydro-2'，3'-dideoxyuridine

2d

IC50

=

214

uM

ALA885085

nM

Plasmodium falciparum

12.

2'，3'-Didehydro-2'，3'-dideoxyuridine

2d

SI

>

3

ALA883676

Plasmodium falciparum 3D7

13.

2'，3'-Didehydro-2'，3'-dideoxyuridine

2d

Ki

>

1

mM

ALA881474

nM

Homo sapiens

14.

2'，3'-Didehydro-2'，3'-dideoxyuridine

2d

Ki

>

1

mM

ALA884808

nM

Leishmania major

15.

2'，3'-Didehydro-2'，3'-dideoxyuridine

2d

Ki

=

298

uM

ALA885372

nM

Plasmodium falciparum 3D7

16.

2'，3'-Didehydro-2'，3'-dideoxyuridine

2d

IC50

>

100

uM

ALA757804

nM

17.

2'，3'-Didehydro-2'，3'-dideoxyuridine

2d

EC50

=

68.3

uM

ALA758934

4.17

nM

18.

2'，3'-Didehydro-2'，3'-dideoxyuridine

2d

Selectivity index

<

2

ALA841097

Homo sapiens

19.

2'，3'-Didehydro-2'，3'-dideoxyuridine

2d

CD50

=

39

uM

ALA712756

uM

Homo sapiens

20.

2'，3'-Didehydro-2'，3'-dideoxyuridine

2d

ED50

>

20

uM

ALA706937

uM

Human immunodeficiency virus 1