| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA2324776 | SI-4, R144C1 | LogD7.4 | 1.15 | ALA3301363 | |||||||
| 2. | ALA2324776 | SI-4, R144C1 | PPB | 98 | % | ALA3301366 | % | |||||
| 3. | ALA2324776 | SI-4, R144C1 | Ratio IC50 | = | 536 | ALA4040181 | ||||||
| 4. | ALA2324776 | SI-4, R144C1 | F | = | 101 | % | ALA4040175 | % | Homo sapiens | |||
| 5. | ALA2324776 | SI-4, R144C1 | Cmax | = | 4.8 | ng/ml | ALA4040174 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | Homo sapiens | ||
| 6. | ALA2324776 | SI-4, R144C1 | t1/2 | = | 4.5 | hr | ALA4040173 | hr | Homo sapiens | |||
| 7. | ALA2324776 | SI-4, R144C1 | Vdss | = | 0.18 | L/Kg | ALA4040172 | L.kg-1 | Homo sapiens | |||
| 8. | ALA2324776 | SI-4, R144C1 | CL free | = | 745 | ml/min.kg | ALA4040171 | mL.min-1.kg-1 | Homo sapiens | |||
| 9. | ALA2324776 | SI-4, R144C1 | CL | = | 1.2 | ml/min.kg | ALA4040170 | mL.min-1.kg-1 | Homo sapiens | |||
| 10. | ALA2324776 | SI-4, R144C1 | Drug uptake | 0 | ALA4040169 | Not Determined | Homo sapiens | |||||
| 11. | ALA2324776 | SI-4, R144C1 | Drug uptake | 0 | ALA4040168 | Not Determined | Homo sapiens | |||||
| 12. | ALA2324776 | SI-4, R144C1 | Drug uptake | 0 | ALA4040167 | Not Determined | Homo sapiens | |||||
| 13. | ALA2324776 | SI-4, R144C1 | pKa | = | 4 | ALA4040165 | ||||||
| 14. | ALA2324776 | SI-4, R144C1 | Tmax | = | 1.5 | hr | ALA4040163 | hr | Canis lupus familiaris | |||
| 15. | ALA2324776 | SI-4, R144C1 | Tmax | = | 1.5 | hr | ALA4040162 | hr | Rattus norvegicus | |||
| 16. | ALA2324776 | SI-4, R144C1 | F | = | 54 | % | ALA4040161 | % | Canis lupus familiaris | |||
| 17. | ALA2324776 | SI-4, R144C1 | Cmax | = | 2890 | ng/ml | ALA4040160 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | Canis lupus familiaris | ||
| 18. | ALA2324776 | SI-4, R144C1 | F | = | 16 | % | ALA4040158 | % | Rattus norvegicus | |||
| 19. | ALA2324776 | SI-4, R144C1 | Cmax | = | 73.2 | ng/ml | ALA4040156 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | Rattus norvegicus | ||
| 20. | ALA2324776 | SI-4, R144C1 | t1/2 | = | 4.6 | hr | ALA4040155 | hr | Canis lupus familiaris |
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