Activities

#	Name	Compound Key	Action Type	Relation	Activity Value	Units	Assay ID	Assay Description	Comment	Assay	Assay Organism
1.	6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile	1	Emax	=	48	%	ALA5134917			%	Homo sapiens
2.	6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile	1	EC50	=	6.25	uM	ALA5134916	5.20		nM	Homo sapiens
3.	6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile	1	EC50	=	0.056	uM	ALA3096582	7.25		nM	Homo sapiens
4.	6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile	1	EC50	=	12	uM	ALA3096580	4.92		nM	Homo sapiens
5.	6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile	1	Papp	=	7.6	ucm/s	ALA3096581			ucm/s	Canis lupus familiaris
6.	6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile	1	Efficacy	=	76	%	ALA3096579			%	Homo sapiens
7.	6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile	1	Efficacy	=	100	%	ALA3096578			%	Homo sapiens
8.	6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile	1	IC50	=	15	uM	ALA3096577	4.82		nM	Homo sapiens
9.	6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile	1	IC50	=	24	uM	ALA3096576	4.62		nM	Homo sapiens
10.	6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile	1	EC50	=	0.9	uM	ALA3096575	6.05		nM	Homo sapiens
11.	6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile	1	Activity		0		ALA3096574		Not Active		Homo sapiens
12.	6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile	1	Activity		0		ALA3096573		Not Active		Homo sapiens
13.	6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile	1	Activity		0		ALA3096572		Not Active		Homo sapiens
14.	6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile	1	Activity		0		ALA3096571		Not Active		Homo sapiens
15.	6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile	1	Activity		0		ALA3096570		Not Active		Rattus norvegicus

1.

6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile

1

Emax

=

48

%

ALA5134917

%

Homo sapiens

2.

6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile

1

EC50

=

6.25

uM

ALA5134916

5.20

nM

Homo sapiens

3.

6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile

1

EC50

=

0.056

uM

ALA3096582

7.25

nM

Homo sapiens

4.

6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile

1

EC50

=

12

uM

ALA3096580

4.92

nM

Homo sapiens

5.

6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile

1

Papp

=

7.6

ucm/s

ALA3096581

ucm/s

Canis lupus familiaris

6.

6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile

1

Efficacy

=

76

%

ALA3096579

%

Homo sapiens

7.

6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile

1

Efficacy

=

100

%

ALA3096578

%

Homo sapiens

8.

6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile

1

IC50

=

15

uM

ALA3096577

4.82

nM

Homo sapiens

9.

6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile

1

IC50

=

24

uM

ALA3096576

4.62

nM

Homo sapiens

10.

6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile

1

EC50

=

0.9

uM

ALA3096575

6.05

nM

Homo sapiens

11.

6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile

1

Activity

0

ALA3096574

Not Active

Homo sapiens

12.

6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile

1

Activity

0

ALA3096573

Not Active

Homo sapiens

13.

6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile

1

Activity

0

ALA3096572

Not Active

Homo sapiens

14.

6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile

1

Activity

0

ALA3096571

Not Active

Homo sapiens

15.

6-[4-[(6-chloroimidazo[1,2-a]pyridin-2-yl)methyl]piperazin-1-yl]pyridine-3-carbonitrile

1

Activity

0

ALA3096570

Not Active

Rattus norvegicus