| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA3121096 | S,R(-)-4b, (1S,6R(-)-4b), S,R-4b | Ki | = | 6.8 | nM | ALA3123356 | 8.17 | nM | Homo sapiens | ||
| 2. | ALA3121096 | S,R(-)-4b, (1S,6R(-)-4b), S,R-4b | Ki | = | 12 | nM | ALA3123355 | 7.92 | nM | Rattus norvegicus | ||
| 3. | ALA3121096 | S,R(-)-4b, (1S,6R(-)-4b), S,R-4b | t1/2 | > | 40 | min | ALA3123341 | hr | ||||
| 4. | ALA3121096 | S,R(-)-4b, (1S,6R(-)-4b), S,R-4b | t1/2 | > | 40 | min | ALA3123339 | hr | Rattus norvegicus | |||
| 5. | ALA3121096 | S,R(-)-4b, (1S,6R(-)-4b), S,R-4b | t1/2 | > | 40 | min | ALA3123340 | hr | Canis lupus familiaris | |||
| 6. | ALA3121096 | S,R(-)-4b, (1S,6R(-)-4b), S,R-4b | t1/2 | > | 40 | min | ALA3123338 | hr | ||||
| 7. | ALA3121096 | S,R(-)-4b, (1S,6R(-)-4b), S,R-4b | t1/2 | > | 40 | min | ALA3123337 | hr | Homo sapiens | |||
| 8. | ALA3121096 | S,R(-)-4b, (1S,6R(-)-4b), S,R-4b | INH | < | 10 | % | ALA3123335 | % | Homo sapiens | |||
| 9. | ALA3121096 | S,R(-)-4b, (1S,6R(-)-4b), S,R-4b | INH | < | 10 | % | ALA3123336 | % | Homo sapiens | |||
| 10. | ALA3121096 | S,R(-)-4b, (1S,6R(-)-4b), S,R-4b | INH | < | 10 | % | ALA3123334 | % | Homo sapiens | |||
| 11. | ALA3121096 | S,R(-)-4b, (1S,6R(-)-4b), S,R-4b | INH | = | 63 | % | ALA3123333 | % | Homo sapiens | |||
| 12. | ALA3121096 | S,R(-)-4b, (1S,6R(-)-4b), S,R-4b | IC50 | = | 6 | uM | ALA3123331 | 5.22 | nM | Homo sapiens | ||
| 13. | ALA3121096 | S,R(-)-4b, (1S,6R(-)-4b), S,R-4b | beta t1/2 | = | 1.6 | hr | ALA3123325 | hr | Rattus norvegicus | |||
| 14. | ALA3121096 | S,R(-)-4b, (1S,6R(-)-4b), S,R-4b | Vdss | = | 3 | L/Kg | ALA3123321 | L.kg-1 | Rattus norvegicus | |||
| 15. | ALA3121096 | S,R(-)-4b, (1S,6R(-)-4b), S,R-4b | CL | = | 22 | ml/min.kg | ALA3123319 | mL.min-1.kg-1 | Rattus norvegicus | |||
| 16. | ALA3121096 | S,R(-)-4b, (1S,6R(-)-4b), S,R-4b | AUC | = | 5144 | ng.hr/ml | ALA3123316 | ng.hr.mL-1 | Rattus norvegicus | |||
| 17. | ALA3121096 | S,R(-)-4b, (1S,6R(-)-4b), S,R-4b | Cmax | = | 649 | ng/ml | ALA3123313 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | Rattus norvegicus | ||
| 18. | ALA3121096 | S,R(-)-4b, (1S,6R(-)-4b), S,R-4b | F | = | 66 | % | ALA3123309 | % | Rattus norvegicus | |||
| 19. | ALA3121096 | S,R(-)-4b, (1S,6R(-)-4b), S,R-4b | BPR | = | 5 | ALA3123306 | ||||||
| 20. | ALA3121096 | S,R(-)-4b, (1S,6R(-)-4b), S,R-4b | EC50 | = | 0.5 | nM | ALA3123259 | 9.30 | nM | Homo sapiens |
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