Activities

#	Name	Compound Key	Action Type	Relation	Activity Value	Units	Assay ID	Assay Description	Comment	Assay	Assay Organism
1.	3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid	21	FC	=	68		ALA4308201				Homo sapiens
2.	3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid	21	FC	=	38		ALA4308200				Homo sapiens
3.	3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid	21	FC	=	3		ALA4308195				Homo sapiens
4.	3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid	21	FC	=	60		ALA4308190				Homo sapiens
5.	3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid	21	FC	=	33		ALA4308185				Homo sapiens
6.	3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid	21	EC50	>	30	uM	ALA4308181			nM	Homo sapiens
7.	3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid	21	EC50	=	13	uM	ALA4308180	4.89		nM	Homo sapiens
8.	3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid	21	EC50	=	9.3	uM	ALA4308179	5.03		nM	Homo sapiens
9.	3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid	21	Activity_index	=	1.56		ALA4055897				Homo sapiens
10.	3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid	21	INH	=	95	%	ALA4055896			%	Homo sapiens
11.	3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid	21	IC50	=	150	uM	ALA689335			nM
12.	3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid	21	Kd	=	0.06	mM	ALA689336	4.22		nM	Human papillomavirus type 16
13.	3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid	21	Plasma selectivity	=	1.56		ALA813228				Homo sapiens
14.	3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid	21	Fibril formation	=	4.9	%	ALA702837			%	Homo sapiens
15.	3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid	21	Fibril formation	=	41.2	%	ALA702836			%	Homo sapiens
16.	3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid	21	pKa		0		ALA813243		No data
17.	3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid	21	Dissociation constant	>	5	mM	ALA818394			nM	Homo sapiens
18.	3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid	21	Dissociation constant	=	0.06	mM	ALA679199	4.22		nM	Human papillomavirus
19.	3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid	21	IC50	=	150	uM	ALA697108	3.82		nM	Human papillomavirus
20.	3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid	21	Kd	=	60	uM	ALA697109	4.22		nM	Human papillomavirus

1.

3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid

21

FC

=

68

ALA4308201

Homo sapiens

2.

3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid

21

FC

=

38

ALA4308200

Homo sapiens

3.

3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid

21

FC

=

3

ALA4308195

Homo sapiens

4.

3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid

21

FC

=

60

ALA4308190

Homo sapiens

5.

3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid

21

FC

=

33

ALA4308185

Homo sapiens

6.

3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid

21

EC50

>

30

uM

ALA4308181

nM

Homo sapiens

7.

3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid

21

EC50

=

13

uM

ALA4308180

4.89

nM

Homo sapiens

8.

3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid

21

EC50

=

9.3

uM

ALA4308179

5.03

nM

Homo sapiens

9.

3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid

21

Activity_index

=

1.56

ALA4055897

Homo sapiens

10.

3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid

21

INH

=

95

%

ALA4055896

%

Homo sapiens

11.

3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid

21

IC50

=

150

uM

ALA689335

nM

12.

3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid

21

Kd

=

0.06

mM

ALA689336

4.22

nM

Human papillomavirus type 16

13.

3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid

21

Plasma selectivity

=

1.56

ALA813228

Homo sapiens

14.

3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid

21

Fibril formation

=

4.9

%

ALA702837

%

Homo sapiens

15.

3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid

21

Fibril formation

=

41.2

%

ALA702836

%

Homo sapiens

16.

3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid

21

pKa

0

ALA813243

No data

17.

3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid

21

Dissociation constant

>

5

mM

ALA818394

nM

Homo sapiens

18.

3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid

21

Dissociation constant

=

0.06

mM

ALA679199

4.22

nM

Human papillomavirus

19.

3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid

21

IC50

=

150

uM

ALA697108

3.82

nM

Human papillomavirus

20.

3'，5'-Dichloro-[1，1'-biphenyl]-4-carboxylic acid

21

Kd

=

60

uM

ALA697109

4.22

nM

Human papillomavirus