Activities

#	Name	Compound Key	Action Type	Relation	Activity Value	Units	Assay ID	Assay Description	Comment	Assay	Assay Organism
1.	3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane	Quarternized tropisetron	Potency		39.811	uM	ALA2114784		inconclusive	nM	Homo sapiens
2.	3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane	Quarternized tropisetron	Potency		3.381	uM	ALA3215185		inconclusive	nM	Homo sapiens
3.	3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane	Quarternized tropisetron	Potency		25.119	uM	ALA1738610		inactive	nM	Homo sapiens
4.	3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane	Quarternized tropisetron	Potency		10.621	uM	ALA1738442		Active	nM	Homo sapiens
5.	3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane	Quarternized tropisetron	Potency		0.398	uM	ALA1794424		inactive	nM	Rattus norvegicus
6.	3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane	Quarternized tropisetron	Potency	=	5.174	um	ALA1614414	5.29	Inconclusive	nM	Saccharomyces cerevisiae
7.	3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane	Quarternized tropisetron	Potency		8.437	uM	ALA1738402		Active	nM	Homo sapiens
8.	3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane	Quarternized tropisetron	Potency		12.589	uM	ALA1738606		inconclusive	nM	Homo sapiens
9.	3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane	Quarternized tropisetron	Potency		4.74	uM	ALA1794499		inconclusive	nM	Homo sapiens
10.	3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane	Quarternized tropisetron	Potency		33.588	uM	ALA1794486		inconclusive	nM	Homo sapiens
11.	3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane	Quarternized tropisetron	Potency		37.686	uM	ALA1794467		inactive	nM	Homo sapiens
12.	3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane	Quarternized tropisetron	Potency		0.164	uM	ALA1794308		inconclusive	nM	Homo sapiens
13.	3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane	Quarternized tropisetron	EC50	=	280	nM	ALA824052	6.55		nM	Homo sapiens
14.	3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane	Quarternized tropisetron	Efficacy	=	13	%	ALA824051			%	Mus musculus
15.	3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane	Quarternized tropisetron	Ki	=	3000	nM	ALA749349	5.52		nM	Homo sapiens
16.	3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane	Quarternized tropisetron	Ki	=	2300	nM	ALA752378	5.64		nM	Homo sapiens
17.	3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane	Quarternized tropisetron	Ki	=	7800	nM	ALA751867	5.11		nM	Homo sapiens
18.	3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane	Quarternized tropisetron	Ki	=	7.2	nM	ALA618130	8.14		nM	Homo sapiens
19.	3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane	Quarternized tropisetron	Ki	=	6.4	nM	ALA750448	8.19		nM	Mus musculus

1.

3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane

Quarternized tropisetron

Potency

39.811

uM

ALA2114784

inconclusive

nM

Homo sapiens

2.

3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane

Quarternized tropisetron

Potency

3.381

uM

ALA3215185

inconclusive

nM

Homo sapiens

3.

3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane

Quarternized tropisetron

Potency

25.119

uM

ALA1738610

inactive

nM

Homo sapiens

4.

3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane

Quarternized tropisetron

Potency

10.621

uM

ALA1738442

Active

nM

Homo sapiens

5.

3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane

Quarternized tropisetron

Potency

0.398

uM

ALA1794424

inactive

nM

Rattus norvegicus

6.

3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane

Quarternized tropisetron

Potency

=

5.174

um

ALA1614414

5.29

Inconclusive

nM

Saccharomyces cerevisiae

7.

3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane

Quarternized tropisetron

Potency

8.437

uM

ALA1738402

Active

nM

Homo sapiens

8.

3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane

Quarternized tropisetron

Potency

12.589

uM

ALA1738606

inconclusive

nM

Homo sapiens

9.

3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane

Quarternized tropisetron

Potency

4.74

uM

ALA1794499

inconclusive

nM

Homo sapiens

10.

3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane

Quarternized tropisetron

Potency

33.588

uM

ALA1794486

inconclusive

nM

Homo sapiens

11.

3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane

Quarternized tropisetron

Potency

37.686

uM

ALA1794467

inactive

nM

Homo sapiens

12.

3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane

Quarternized tropisetron

Potency

0.164

uM

ALA1794308

inconclusive

nM

Homo sapiens

13.

3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane

Quarternized tropisetron

EC50

=

280

nM

ALA824052

6.55

nM

Homo sapiens

14.

3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane

Quarternized tropisetron

Efficacy

=

13

%

ALA824051

%

Mus musculus

15.

3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane

Quarternized tropisetron

Ki

=

3000

nM

ALA749349

5.52

nM

Homo sapiens

16.

3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane

Quarternized tropisetron

Ki

=

2300

nM

ALA752378

5.64

nM

Homo sapiens

17.

3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane

Quarternized tropisetron

Ki

=

7800

nM

ALA751867

5.11

nM

Homo sapiens

18.

3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane

Quarternized tropisetron

Ki

=

7.2

nM

ALA618130

8.14

nM

Homo sapiens

19.

3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane

Quarternized tropisetron

Ki

=

6.4

nM

ALA750448

8.19

nM

Mus musculus