| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA3403190 | 15, ONO-4310321 | INH | = | 99 | % | ALA3404934 | % | Cavia porcellus | |||
| 2. | ALA3403190 | 15, ONO-4310321 | INH | = | 45 | % | ALA3404933 | % | Cavia porcellus | |||
| 3. | ALA3403190 | 15, ONO-4310321 | INH | 0 | ALA3404932 | Dose-dependent effect | % | Cavia porcellus | ||||
| 4. | ALA3403190 | 15, ONO-4310321 | Vdss | = | 208 | ml/kg | ALA3404931 | L.kg-1 | Rattus norvegicus | |||
| 5. | ALA3403190 | 15, ONO-4310321 | AUC | = | 28 | ug.hr/ml | ALA3404930 | ng.hr.mL-1 | Rattus norvegicus | |||
| 6. | ALA3403190 | 15, ONO-4310321 | t1/2 | = | 7.1 | hr | ALA3404929 | hr | Rattus norvegicus | |||
| 7. | ALA3403190 | 15, ONO-4310321 | CL | = | 0.65 | ml/min.kg | ALA3404928 | mL.min-1.kg-1 | Rattus norvegicus | |||
| 8. | ALA3403190 | 15, ONO-4310321 | F | = | 100 | % | ALA3404927 | % | Rattus norvegicus | |||
| 9. | ALA3403190 | 15, ONO-4310321 | AUC | = | 324 | ug.hr/ml | ALA3404925 | ng.hr.mL-1 | Rattus norvegicus | |||
| 10. | ALA3403190 | 15, ONO-4310321 | t1/2 | = | 4.7 | hr | ALA3404766 | hr | Rattus norvegicus | |||
| 11. | ALA3403190 | 15, ONO-4310321 | Cmax | = | 33 | ug ml-1 | ALA3404764 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | Rattus norvegicus | ||
| 12. | ALA3403190 | 15, ONO-4310321 | Papp | = | 0.8 | 10'-6 cm/s | ALA3404762 | 10'-6 cm/s | ||||
| 13. | ALA3403190 | 15, ONO-4310321 | Papp | = | 6.9 | 10'-6 cm/s | ALA3404761 | 10'-6 cm/s | ||||
| 14. | ALA3403190 | 15, ONO-4310321 | Papp | = | 6.9 | 10'-6 cm/s | ALA3404760 | 10'-6 cm/s | ||||
| 15. | ALA3403190 | 15, ONO-4310321 | IC50 | = | 25 | nM | ALA3404759 | 7.60 | nM | Homo sapiens | ||
| 16. | ALA3403190 | 15, ONO-4310321 | IC50 | = | 13 | nM | ALA3404758 | 7.89 | nM | Homo sapiens | ||
| 17. | ALA3403190 | 15, ONO-4310321 | INH | = | 99 | % | ALA3599423 | % | Cavia porcellus | |||
| 18. | ALA3403190 | 15, ONO-4310321 | F | = | 100 | % | ALA3599266 | % | Rattus norvegicus | |||
| 19. | ALA3403190 | 15, ONO-4310321 | F | = | 26 | % | ALA3599265 | % | Cavia porcellus | |||
| 20. | ALA3403190 | 15, ONO-4310321 | Papp | = | 1.8 | ucm/s | ALA3599264 | ucm/s |
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