| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA3403753 | 14d | INH | = | 70 | % | ALA3405068 | % | Rattus norvegicus | |||
| 2. | ALA3403753 | 14d | INH | 0 | ALA3405067 | Dose-dependent effect | % | Rattus norvegicus | ||||
| 3. | ALA3403753 | 14d | INH | = | 75 | % | ALA3405066 | % | Rattus norvegicus | |||
| 4. | ALA3403753 | 14d | INH | = | 68 | % | ALA3405065 | % | Rattus norvegicus | |||
| 5. | ALA3403753 | 14d | INH | = | 9 | % | ALA3405064 | % | Rattus norvegicus | |||
| 6. | ALA3403753 | 14d | solubility | < | 5 | ug ml-1 | ALA3405062 | ug.mL-1 | ||||
| 7. | ALA3403753 | 14d | F | = | 62 | % | ALA3405061 | % | Rattus norvegicus | |||
| 8. | ALA3403753 | 14d | AUC | = | 11219 | ng.hr/ml | ALA3405060 | ng.hr.mL-1 | Rattus norvegicus | |||
| 9. | ALA3403753 | 14d | Cmax | = | 807 | ng/ml | ALA3405059 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | Rattus norvegicus | ||
| 10. | ALA3403753 | 14d | Vdss | = | 5 | L/Kg | ALA3405058 | L.kg-1 | Rattus norvegicus | |||
| 11. | ALA3403753 | 14d | CL | = | 8 | ml/min.kg | ALA3405057 | mL.min-1.kg-1 | Rattus norvegicus | |||
| 12. | ALA3403753 | 14d | AUC | = | 1824 | ng.hr/ml | ALA3405056 | ng.hr.mL-1 | Rattus norvegicus | |||
| 13. | ALA3403753 | 14d | beta t1/2 | = | 8 | hr | ALA3405055 | hr | Rattus norvegicus | |||
| 14. | ALA3403753 | 14d | permeability | = | 0.66 | 10'-6 cm/s | ALA3405054 | 10'-6 cm/s | ||||
| 15. | ALA3403753 | 14d | Drug metabolism | < | 5 | % | ALA3405053 | % | Homo sapiens | |||
| 16. | ALA3403753 | 14d | Drug metabolism | = | 10 | % | ALA3405052 | % | Rattus norvegicus | |||
| 17. | ALA3403753 | 14d | IC50 | > | 100 | uM | ALA3405051 | nM | Cricetulus griseus | |||
| 18. | ALA3403753 | 14d | IC50 | = | 740 | nM | ALA3405050 | 6.13 | nM | Rattus norvegicus | ||
| 19. | ALA3403753 | 14d | IC50 | = | 630 | nM | ALA3405049 | 6.20 | nM | Homo sapiens | ||
| 20. | ALA3403753 | 14d | IC50 | = | 440 | nM | ALA3405048 | 6.36 | nM | Homo sapiens |
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