# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | ALA3415453 | 18 | F | = | 3 | % | ALA3420564 | % | Mus musculus | |||
2. | ALA3415453 | 18 | Cmax | = | 57 | ug ml-1 | ALA3420795 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | Mus musculus | ||
3. | ALA3415453 | 18 | AUC | = | 278 | ug/L/h | ALA3420563 | ng.hr.mL-1 | Mus musculus | |||
4. | ALA3415453 | 18 | t1/2 | = | 1.1 | hr | ALA3420561 | hr | Mus musculus | |||
5. | ALA3415453 | 18 | AUC | = | 1065 | ug/L/h | ALA3420559 | ng.hr.mL-1 | Mus musculus | |||
6. | ALA3415453 | 18 | CL | = | 156 | ml/min.kg | ALA3420558 | mL.min-1.kg-1 | Mus musculus | |||
7. | ALA3415453 | 18 | INH | 0 | ALA3420557 | Dose-dependent effect | % | Homo sapiens | ||||
8. | ALA3415453 | 18 | INH | 0 | ALA3420555 | Not Active | % | Homo sapiens | ||||
9. | ALA3415453 | 18 | CLH | = | 44 | ml/min.kg | ALA3420553 | mL.min-1.kg-1 | Mus musculus | |||
10. | ALA3415453 | 18 | CLH | = | 8 | ml/min.kg | ALA3420552 | mL.min-1.kg-1 | Homo sapiens | |||
11. | ALA3415453 | 18 | solubility | < | 1 | ug ml-1 | ALA3420551 | ug.mL-1 | ||||
12. | ALA3415453 | 18 | IC50 | = | 0.12 | uM | ALA3420550 | 6.92 | nM | Homo sapiens | ||
13. | ALA3415453 | 18 | IC50 | = | 0.16 | uM | ALA3420277 | 6.80 | nM | Homo sapiens | ||
14. | ALA3415453 | 18 | IC50 | = | 14.3 | uM | ALA3420276 | 4.84 | nM | Homo sapiens | ||
15. | ALA3415453 | 18 | EC50 | = | 1.4 | uM | ALA3420275 | 5.85 | nM | Homo sapiens |