Activities

#	Name	Compound Key	Action Type	Relation	Activity Value	Units	Assay ID	Assay Description	Comment	Assay	Assay Organism
1.	2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one	[14C]-RRx-001	IC50	=	1250	nM	ALA5138134	5.90		nM
2.	2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one	[14C]-RRx-001	inhibition	=	5.87	%	ALA4808150			%	Homo sapiens
3.	2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one	[14C]-RRx-001	inhibition	=	8.93	%	ALA4808149			%	Homo sapiens
4.	2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one	[14C]-RRx-001	Inhibition	=	28.94	%	ALA4303805			%	Severe acute respiratory syndrome coronavirus 2
5.	2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one	[14C]-RRx-001	inhibition	=	0.03	%	ALA4513082			%	Severe acute respiratory syndrome coronavirus 2
6.	2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one	[14C]-RRx-001	Drug metabolism		0		ALA3541619		metabolite_detected		Homo sapiens
7.	2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one	[14C]-RRx-001	Drug metabolism		0		ALA3541620		metabolite_detected		Rattus norvegicus
8.	2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one	[14C]-RRx-001	Drug metabolism		0		ALA3541621		metabolite_detected		Homo sapiens
9.	2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one	[14C]-RRx-001	Drug metabolism		0		ALA3541622		metabolite_detected		Rattus norvegicus
10.	2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one	[14C]-RRx-001	PB		0		ALA3541635		Active	%
11.	2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one	[14C]-RRx-001	Drug excretion	=	1.5	%	ALA3539501			%
12.	2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one	[14C]-RRx-001	Drug excretion	=	0.3	%	ALA3539500			%
13.	2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one	[14C]-RRx-001	Drug excretion	=	0.06	%	ALA3539506			%
14.	2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one	[14C]-RRx-001	Drug metabolism		0		ALA3541623		metabolite_detected		Homo sapiens
15.	2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one	[14C]-RRx-001	Drug metabolism		0		ALA3541624		metabolite_detected		Rattus norvegicus
16.	2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one	[14C]-RRx-001	Drug metabolism		0		ALA3541625		metabolite_detected		Homo sapiens
17.	2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one	[14C]-RRx-001	Drug metabolism		0		ALA3541626		metabolite_detected		Rattus norvegicus
18.	2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one	[14C]-RRx-001	Drug metabolism		0		ALA3541627		metabolite_detected		Homo sapiens
19.	2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one	[14C]-RRx-001	Drug metabolism		0		ALA3541628		metabolite_detected		Rattus norvegicus
20.	2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one	[14C]-RRx-001	Drug metabolism		0		ALA3541629		metabolite_detected		Homo sapiens

1.

2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one

[14C]-RRx-001

IC50

=

1250

nM

ALA5138134

5.90

nM

2.

2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one

[14C]-RRx-001

inhibition

=

5.87

%

ALA4808150

%

Homo sapiens

3.

2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one

[14C]-RRx-001

inhibition

=

8.93

%

ALA4808149

%

Homo sapiens

4.

2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one

[14C]-RRx-001

Inhibition

=

28.94

%

ALA4303805

%

Severe acute respiratory syndrome coronavirus 2

5.

2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one

[14C]-RRx-001

inhibition

=

0.03

%

ALA4513082

%

Severe acute respiratory syndrome coronavirus 2

6.

2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one

[14C]-RRx-001

Drug metabolism

0

ALA3541619

metabolite_detected

Homo sapiens

7.

2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one

[14C]-RRx-001

Drug metabolism

0

ALA3541620

metabolite_detected

Rattus norvegicus

8.

2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one

[14C]-RRx-001

Drug metabolism

0

ALA3541621

metabolite_detected

Homo sapiens

9.

2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one

[14C]-RRx-001

Drug metabolism

0

ALA3541622

metabolite_detected

Rattus norvegicus

10.

2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one

[14C]-RRx-001

PB

0

ALA3541635

Active

%

11.

2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one

[14C]-RRx-001

Drug excretion

=

1.5

%

ALA3539501

%

12.

2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one

[14C]-RRx-001

Drug excretion

=

0.3

%

ALA3539500

%

13.

2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one

[14C]-RRx-001

Drug excretion

=

0.06

%

ALA3539506

%

14.

2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one

[14C]-RRx-001

Drug metabolism

0

ALA3541623

metabolite_detected

Homo sapiens

15.

2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one

[14C]-RRx-001

Drug metabolism

0

ALA3541624

metabolite_detected

Rattus norvegicus

16.

2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one

[14C]-RRx-001

Drug metabolism

0

ALA3541625

metabolite_detected

Homo sapiens

17.

2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one

[14C]-RRx-001

Drug metabolism

0

ALA3541626

metabolite_detected

Rattus norvegicus

18.

2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one

[14C]-RRx-001

Drug metabolism

0

ALA3541627

metabolite_detected

Homo sapiens

19.

2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one

[14C]-RRx-001

Drug metabolism

0

ALA3541628

metabolite_detected

Rattus norvegicus

20.

2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one

[14C]-RRx-001

Drug metabolism

0

ALA3541629

metabolite_detected

Homo sapiens