| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA3527376 | [14C]GSK2251052 | Drug recovery | = | 6 | % | ALA3534024 | % | ||||
| 2. | ALA3527376 | [14C]GSK2251052 | Drug recovery | = | 83.1 | % | ALA3534023 | % | ||||
| 3. | ALA3527376 | [14C]GSK2251052 | Tmax | = | 0.917 | hr | ALA3534022 | hr | Homo sapiens | |||
| 4. | ALA3527376 | [14C]GSK2251052 | t1/2 | = | 96 | hr | ALA3534021 | hr | Homo sapiens | |||
| 5. | ALA3527376 | [14C]GSK2251052 | Vdss | = | 348 | l | ALA3533704 | l | Homo sapiens | |||
| 6. | ALA3527376 | [14C]GSK2251052 | CL | = | 7.7 | L/hr | ALA3533703 | L/hr | Homo sapiens | |||
| 7. | ALA3527376 | [14C]GSK2251052 | Cmax | = | 24.3 | ug ml-1 | ALA3533702 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | Homo sapiens | ||
| 8. | ALA3527376 | [14C]GSK2251052 | AUC | = | 195 | microg.hr/mL | ALA3533701 | ng.hr.mL-1 | Homo sapiens | |||
| 9. | ALA3527376 | [14C]GSK2251052 | AUCt | = | 191 | microg.hr/mL | ALA3533700 | ng.hr.mL-1 | Homo sapiens | |||
| 10. | ALA3527376 | [14C]GSK2251052 | Drug metabolism | 0 | ALA3537505 | metabolite_not_detected | ||||||
| 11. | ALA3527376 | [14C]GSK2251052 | Drug metabolism | 0 | ALA3537504 | metabolite_not_detected | ||||||
| 12. | ALA3527376 | [14C]GSK2251052 | Drug metabolism | 0 | ALA3537503 | metabolite_not_detected | Homo sapiens | |||||
| 13. | ALA3527376 | [14C]GSK2251052 | Drug metabolism | 0 | ALA3534485 | metabolite_not_detected | Homo sapiens | |||||
| 14. | ALA3527376 | [14C]GSK2251052 | Drug metabolism | 0 | ALA3534484 | metabolite_not_detected | ||||||
| 15. | ALA3527376 | [14C]GSK2251052 | Drug metabolism | 0 | ALA3534483 | metabolite_not_detected | ||||||
| 16. | ALA3527376 | [14C]GSK2251052 | Drug metabolism | 0 | ALA3534482 | metabolite_not_detected | ||||||
| 17. | ALA3527376 | [14C]GSK2251052 | Drug metabolism | 0 | ALA3534481 | metabolite_not_detected | Homo sapiens | |||||
| 18. | ALA3527376 | [14C]GSK2251052 | Drug metabolism | 0 | ALA3534480 | metabolite_not_detected | ||||||
| 19. | ALA3527376 | [14C]GSK2251052 | Drug metabolism | 0 | ALA3534479 | metabolite_not_detected | ||||||
| 20. | ALA3527376 | [14C]GSK2251052 | Drug metabolism | 0 | ALA3531200 | metabolite_not_detected |
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