# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | ALA3622445 | 19 | IC50 | = | 3483 | nM | ALA3625376 | 5.46 | nM | |||
2. | ALA3622445 | 19 | Activity | 0 | ALA3625374 | Not Active | Macaca mulatta | |||||
3. | ALA3622445 | 19 | Cp(f) | = | 279 | nM | ALA3625373 | nM | Macaca mulatta | |||
4. | ALA3622445 | 19 | Cp(f) | = | 73 | nM | ALA3625372 | nM | Macaca mulatta | |||
5. | ALA3622445 | 19 | Cp(f) | = | 19 | nM | ALA3625371 | nM | Macaca mulatta | |||
6. | ALA3622445 | 19 | INH | = | 98 | % | ALA3625370 | % | Macaca mulatta | |||
7. | ALA3622445 | 19 | INH | = | 71 | % | ALA3625369 | % | Macaca mulatta | |||
8. | ALA3622445 | 19 | INH | = | 48 | % | ALA3625368 | % | Macaca mulatta | |||
9. | ALA3622445 | 19 | Fu | = | 31 | % | ALA3625367 | Macaca mulatta | ||||
10. | ALA3622445 | 19 | INH | 0 | ALA3625366 | Dose-dependent effect | % | Macaca mulatta | ||||
11. | ALA3622445 | 19 | INH | 0 | ALA3625365 | Active | % | Rattus norvegicus | ||||
12. | ALA3622445 | 19 | IC50 | = | 12 | nM | ALA3625364 | 7.92 | nM | |||
13. | ALA3622445 | 19 | t1/2 | = | 7.8 | hr | ALA3625360 | hr | Macaca mulatta | |||
14. | ALA3622445 | 19 | CL | = | 3 | ml/min.kg | ALA3625359 | mL.min-1.kg-1 | Macaca mulatta | |||
15. | ALA3622445 | 19 | AUC | = | 16.26 | uM.hr.Kg/mg | ALA3625358 | uM.hr.Kg/mg | Macaca mulatta | |||
16. | ALA3622445 | 19 | F | = | 100 | % | ALA3625357 | % | Macaca mulatta | |||
17. | ALA3622445 | 19 | CL | < | 20 | ml/min.kg | ALA3625356 | mL.min-1.kg-1 | ||||
18. | ALA3622445 | 19 | PPB | = | 31 | % | ALA3625355 | % | Macaca mulatta | |||
19. | ALA3622445 | 19 | PPB | = | 25 | % | ALA3625354 | % | Rattus norvegicus | |||
20. | ALA3622445 | 19 | IC50 | > | 50000 | nM | ALA3625353 | nM | Homo sapiens |