Activities

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Activities

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#	Name	Compound Key	Action Type	Relation	Activity Value	Units	Assay ID	Assay Description	Comment	Assay	Assay Organism
1.	PF-06282999	8; PF-06282999	FC	=	1.91		ALA5130504				Homo sapiens
2.	PF-06282999	8; PF-06282999	Ratio IC50	=	5		ALA5130503
3.	PF-06282999	8; PF-06282999	IC50	=	0.99	uM	ALA5130502	6.00		nM	Homo sapiens
4.	PF-06282999	8; PF-06282999	IC50	=	35.5	uM	ALA5130501	4.45		nM	Homo sapiens
5.	PF-06282999	8; PF-06282999	IC50	=	187	nM	ALA5130499	6.73		nM	Homo sapiens
6.	PF-06282999	8; PF-06282999	Activity	=	57	%	ALA5246971			%	Homo sapiens
7.	PF-06282999	8; PF-06282999	F	=	75	%	ALA3636545			%	Canis lupus familiaris
8.	PF-06282999	8; PF-06282999	F	=	86	%	ALA3636544			%	Rattus norvegicus
9.	PF-06282999	8; PF-06282999	Tmax	=	0.7	hr	ALA3636541			hr	Canis lupus familiaris
10.	PF-06282999	8; PF-06282999	Tmax	=	0.78	hr	ALA3636540			hr	Rattus norvegicus
11.	PF-06282999	8; PF-06282999	beta t1/2	=	2.2	hr	ALA3636537			hr	Canis lupus familiaris
12.	PF-06282999	8; PF-06282999	beta t1/2	=	0.75	hr	ALA3636536			hr	Rattus norvegicus
13.	PF-06282999	8; PF-06282999	Vdss	=	0.54	L/Kg	ALA3636533			L.kg-1	Canis lupus familiaris
14.	PF-06282999	8; PF-06282999	Vdss	=	2.13	L/Kg	ALA3636532			L.kg-1	Rattus norvegicus
15.	PF-06282999	8; PF-06282999	pKinact	=	2.43		ALA3636509				Homo sapiens
16.	PF-06282999	8; PF-06282999	EC50	=	3.8	uM	ALA3637267	5.42		nM	Macaca fascicularis
17.	PF-06282999	8; PF-06282999	Activity		0		ALA3637266		Non-toxic		Salmonella enterica subsp. enterica serovar Typhi
18.	PF-06282999	8; PF-06282999	Drugexcretion	=	26	%	ALA3637265			%
19.	PF-06282999	8; PF-06282999	Drugexcretion	=	26	%	ALA3637264			%
20.	PF-06282999	8; PF-06282999	Drugexcretion	=	26	%	ALA3637263			%