| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA3809490 | (R)-23l | PPB | = | 62.25 | % | ALA3812104 | % | ||||
| 2. | ALA3809490 | (R)-23l | F | = | 7 | % | ALA3812103 | % | Rattus norvegicus | |||
| 3. | ALA3809490 | (R)-23l | CL(app) | = | 2.275 | L/hr/kg | ALA3812102 | mL.min-1.kg-1 | Rattus norvegicus | |||
| 4. | ALA3809490 | (R)-23l | t1/2 | = | 1.1 | hr | ALA3812101 | hr | Rattus norvegicus | |||
| 5. | ALA3809490 | (R)-23l | t1/2 | = | 1.22 | hr | ALA3812100 | hr | Rattus norvegicus | |||
| 6. | ALA3809490 | (R)-23l | MRT | = | 2.94 | hr | ALA3812099 | hr | Rattus norvegicus | |||
| 7. | ALA3809490 | (R)-23l | MRT | = | 3.54 | hr | ALA3812098 | hr | Rattus norvegicus | |||
| 8. | ALA3809490 | (R)-23l | AUC | = | 4396 | ng/mL.hr | ALA3812097 | ng.hr.mL-1 | Rattus norvegicus | |||
| 9. | ALA3809490 | (R)-23l | AUC | = | 613.2 | ng/mL.hr | ALA3812096 | ng.hr.mL-1 | Rattus norvegicus | |||
| 10. | ALA3809490 | (R)-23l | Cmax | = | 2425.1 | ng/ml | ALA3812095 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | Rattus norvegicus | ||
| 11. | ALA3809490 | (R)-23l | Cmax | = | 108.6 | ng/ml | ALA3812094 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | Rattus norvegicus | ||
| 12. | ALA3809490 | (R)-23l | Tmax | = | 0.083 | hr | ALA3812093 | hr | Rattus norvegicus | |||
| 13. | ALA3809490 | (R)-23l | Tmax | = | 0.5 | hr | ALA3812092 | hr | Rattus norvegicus | |||
| 14. | ALA3809490 | (R)-23l | Activity | 0 | ALA3812091 | Dose-dependent effect | Rattus norvegicus | |||||
| 15. | ALA3809490 | (R)-23l | MED | = | 3 | mg kg-1 | ALA3812091 | mg kg-1 | Rattus norvegicus | |||
| 16. | ALA3809490 | (R)-23l | Activity | 0 | ALA3812090 | Dose-dependent effect | Rattus norvegicus | |||||
| 17. | ALA3809490 | (R)-23l | MED | = | 10 | mg kg-1 | ALA3812090 | mg kg-1 | Rattus norvegicus | |||
| 18. | ALA3809490 | (R)-23l | Ratio IC50 | = | 3.9 | ALA3812089 | ||||||
| 19. | ALA3809490 | (R)-23l | IC50 | = | 297.8 | nM | ALA3812088 | 6.53 | nM | Rattus norvegicus | ||
| 20. | ALA3809490 | (R)-23l | IC50 | = | 76.8 | nM | ALA3812087 | 7.12 | nM |
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