Activities

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Activities

Activities

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#	Name	Compound Key	Action Type	Relation	Activity Value	Units	Assay ID	Assay Description	Comment	Assay	Assay Organism
1.	ALA4060253	1h	permeability	=	337	nm/s	ALA4410492			nm/s
2.	ALA4060253	1h	F	=	60.6	%	ALA4410486			%
3.	ALA4060253	1h	Vdss	=	269	ml/kg	ALA4410485			L.kg-1
4.	ALA4060253	1h	CL	=	88	ml/hr/kg	ALA4410484			mL.min-1.kg-1
5.	ALA4060253	1h	t1/2	>	8	hr	ALA4410483			hr
6.	ALA4060253	1h	MRT	=	3.69	hr	ALA4410482			hr
7.	ALA4060253	1h	AUC	=	6880.6	ng.hr/ml	ALA4410481			ng.hr.mL-1
8.	ALA4060253	1h	Cmax	=	1114.7	ng/ml	ALA4410480		standard_value was converted from ug.mL-1 to nM using the parent compound MW \| standard_value was converted from ug.mL-1 to nM using the parent compound MW \| standard_value was converted from ug.mL-1 to nM using the parent compound MW \| standard_value was converted from ug.mL-1 to nM using the parent compound MW \| standard_value was converted from ug.mL-1 to nM using the parent compound MW \| standard_value was converted from ug.mL-1 to nM using the parent compound MW	nM
9.	ALA4060253	1h	Stability	=	65	microL/min/mg	ALA4410475			microL/min/mg
10.	ALA4060253	1h	Stability	=	27	microL/min/mg	ALA4410474			microL/min/mg
11.	ALA4060253	1h	permeability	=	272	nm/s	ALA4410473			nm/s
12.	ALA4060253	1h	INH	=	84	%	ALA4410471			%	Homo sapiens
13.	ALA4060253	1h	INH	=	84	%	ALA4410470			%	Homo sapiens
14.	ALA4060253	1h	Ratio IC50	=	94.4		ALA4410469
15.	ALA4060253	1h	IC50	=	170	nM	ALA4410468	6.77		nM	Homo sapiens
16.	ALA4060253	1h	IC50	=	1.8	nM	ALA4410467	8.74		nM	Homo sapiens
17.	ALA4060253	1h	IC50	=	36	nM	ALA4410466	7.44		nM	Mus musculus
18.	ALA4060253	1h	IC50	=	0.18	nM	ALA4410465	9.74		nM	Mus musculus
19.	ALA4060253	1h	Activity	>	20	%	ALA4410464			%
20.	ALA4060253	1h	INH	=	87	%	ALA4027529			%	Homo sapiens