| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA4082159 | 23a; GSK656 | MTD | = | 300 | mg kg-1 | ALA4020373 | mg kg-1 | Mus musculus | |||
| 2. | ALA4082159 | 23a; GSK656 | MTD | = | 100 | mg kg-1 | ALA4020371 | mg kg-1 | Mus musculus | |||
| 3. | ALA4082159 | 23a; GSK656 | Activity | 0 | ALA4020370 | Dose-dependent effect | Mycobacterium tuberculosis | |||||
| 4. | ALA4082159 | 23a; GSK656 | Activity | = | 4.4 | log10CFU | ALA4020369 | log10CFU | Mycobacterium tuberculosis | |||
| 5. | ALA4082159 | 23a; GSK656 | Activity | = | 4.3 | log10CFU | ALA4020368 | log10CFU | Mycobacterium tuberculosis | |||
| 6. | ALA4082159 | 23a; GSK656 | Activity | = | 4.6 | log10CFU | ALA4020367 | log10CFU | Mycobacterium tuberculosis | |||
| 7. | ALA4082159 | 23a; GSK656 | Activity | = | 4.7 | log10CFU | ALA4020366 | log10CFU | Mycobacterium tuberculosis | |||
| 8. | ALA4082159 | 23a; GSK656 | Activity | = | 6 | log10CFU | ALA4020365 | log10CFU | Mycobacterium tuberculosis | |||
| 9. | ALA4082159 | 23a; GSK656 | Activity | = | 6.4 | log10CFU | ALA4020364 | log10CFU | Mycobacterium tuberculosis | |||
| 10. | ALA4082159 | 23a; GSK656 | ED99 | = | 0.4 | mg kg-1 | ALA4020362 | mg kg-1 | Mycobacterium tuberculosis | |||
| 11. | ALA4082159 | 23a; GSK656 | F | = | 100 | % | ALA4020338 | % | Mus musculus | |||
| 12. | ALA4082159 | 23a; GSK656 | AUC/dose | = | 2.94 | hr.microg/ml | ALA4020336 | hr.microg/ml | Mus musculus | |||
| 13. | ALA4082159 | 23a; GSK656 | AUC | = | 88.24 | hr.microg/ml | ALA4020335 | ng.hr.mL-1 | Mus musculus | |||
| 14. | ALA4082159 | 23a; GSK656 | Tmax | = | 0.9 | hr | ALA4020334 | hr | Mus musculus | |||
| 15. | ALA4082159 | 23a; GSK656 | Cmax | = | 17.76 | ug ml-1 | ALA4020333 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | Mus musculus | ||
| 16. | ALA4082159 | 23a; GSK656 | CL | = | 8.5 | ml/min.kg | ALA4020332 | mL.min-1.kg-1 | Mus musculus | |||
| 17. | ALA4082159 | 23a; GSK656 | AUC/dose | = | 2.03 | ug.hr/mL/mg/kg | ALA4020331 | ug.hr/mL/mg/kg | Mus musculus | |||
| 18. | ALA4082159 | 23a; GSK656 | AUC | = | 11.12 | hr.microg/ml | ALA4020330 | ng.hr.mL-1 | Mus musculus | |||
| 19. | ALA4082159 | 23a; GSK656 | t1/2 | = | 3.6 | hr | ALA4020329 | hr | Mus musculus | |||
| 20. | ALA4082159 | 23a; GSK656 | Vdss | = | 2.3 | L/Kg | ALA4020328 | L.kg-1 | Mus musculus |
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