| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA4084988 | 10; Tab 1, Entry 6; Tab 2, Entry 1 | Cmax | = | 3500 | ng/ml | ALA4047378 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | Mus musculus | ||
| 2. | ALA4084988 | 10; Tab 1, Entry 6; Tab 2, Entry 1 | Vdss | = | 0.55 | L/Kg | ALA4047377 | L.kg-1 | Mus musculus | |||
| 3. | ALA4084988 | 10; Tab 1, Entry 6; Tab 2, Entry 1 | CL | = | 0.36 | L/hr/kg | ALA4047376 | mL.min-1.kg-1 | Mus musculus | |||
| 4. | ALA4084988 | 10; Tab 1, Entry 6; Tab 2, Entry 1 | F | = | 54 | % | ALA4047375 | % | Mus musculus | |||
| 5. | ALA4084988 | 10; Tab 1, Entry 6; Tab 2, Entry 1 | t1/2 | = | 2.3 | hr | ALA4047374 | hr | Mus musculus | |||
| 6. | ALA4084988 | 10; Tab 1, Entry 6; Tab 2, Entry 1 | t1/2 | = | 1.5 | hr | ALA4047373 | hr | Mus musculus | |||
| 7. | ALA4084988 | 10; Tab 1, Entry 6; Tab 2, Entry 1 | IC50 | = | 0.002 | uM | ALA4047364 | 8.70 | nM | Homo sapiens | ||
| 8. | ALA4084988 | 10; Tab 1, Entry 6; Tab 2, Entry 1 | IC50 | = | 0.047 | uM | ALA4047365 | 7.33 | nM | Homo sapiens | ||
| 9. | ALA4084988 | 10; Tab 1, Entry 6; Tab 2, Entry 1 | IC50 | = | 0.085 | uM | ALA4047361 | 7.07 | nM | Homo sapiens | ||
| 10. | ALA4084988 | 10; Tab 1, Entry 6; Tab 2, Entry 1 | permeability | = | 26 | 10'-7 cm/s | ALA4047366 | 10'-7 cm/s | Homo sapiens | |||
| 11. | ALA4084988 | 10; Tab 1, Entry 6; Tab 2, Entry 1 | CLH | = | 35 | % | ALA4047368 | % | Homo sapiens | |||
| 12. | ALA4084988 | 10; Tab 1, Entry 6; Tab 2, Entry 1 | Therm_solubility | = | 42 | uM | ALA4047369 | nM | ||||
| 13. | ALA4084988 | 10; Tab 1, Entry 6; Tab 2, Entry 1 | AUC | = | 15000 | ng.hr/ml | ALA4047372 | ng.hr.mL-1 | Mus musculus | |||
| 14. | ALA4084988 | 10; Tab 1, Entry 6; Tab 2, Entry 1 | IC50 | = | 0.001 | uM | ALA4047362 | 9.00 | nM | Homo sapiens | ||
| 15. | ALA4084988 | 10; Tab 1, Entry 6; Tab 2, Entry 1 | IC50 | = | 0.006 | uM | ALA4047363 | 8.22 | nM | Homo sapiens |
The page will load shortly, Thanks for your patience!