| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  HSK3486 | 2; HSK3486 | INH | 0 | ALA4043672 | Dose-dependent effect | % | |||||
| 2. | HSK3486 | 2; HSK3486 | Activity | = | 4.8 | mg kg-1 | ALA4043686 | mg kg-1 | Mus musculus | |||
| 3. | HSK3486 | 2; HSK3486 | LD50 | = | 9.9 | mg kg-1 | ALA4043685 | mg.kg-1 | Mus musculus | |||
| 4. | HSK3486 | 2; HSK3486 | ED50 | = | 1.5 | mg kg-1 | ALA4043684 | mg.kg-1 | Mus musculus | |||
| 5. | HSK3486 | 2; HSK3486 | Time | = | 64.8 | s | ALA4043683 | hr | Mus musculus | |||
| 6. | HSK3486 | 2; HSK3486 | Time | = | 313.43 | s | ALA4043682 | hr | Mus musculus | |||
| 7. | HSK3486 | 2; HSK3486 | Time | = | 21.86 | s | ALA4043681 | hr | Mus musculus | |||
| 8. | HSK3486 | 2; HSK3486 | Cmax | = | 834 | mg/ml | ALA4043679 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | Rattus norvegicus | ||
| 9. | HSK3486 | 2; HSK3486 | CL | = | 100 | ml/kg.min | ALA4043678 | ml/kg.min | Rattus norvegicus | |||
| 10. | HSK3486 | 2; HSK3486 | Vdss | = | 2.02 | L/Kg | ALA4043677 | L.kg-1 | Rattus norvegicus | |||
| 11. | HSK3486 | 2; HSK3486 | t1/2 | = | 28 | min | ALA4043676 | hr | Rattus norvegicus | |||
| 12. | HSK3486 | 2; HSK3486 | AUCt | = | 164 | ng.hr/ml | ALA4043675 | ng.hr.mL-1 | Rattus norvegicus | |||
| 13. | HSK3486 | 2; HSK3486 | INH | = | 34 | % | ALA4043674 | % | ||||
| 14. | HSK3486 | 2; HSK3486 | INH | = | 85 | % | ALA4043673 | % | ||||
| 15. | HSK3486 | 2; HSK3486 | F | = | 7.7 | % | ALA4020409 | % | Canis lupus familiaris | |||
| 16. | HSK3486 | 2; HSK3486 | AUCt | = | 162 | ng.hr/ml | ALA4020407 | ng.hr.mL-1 | Canis lupus familiaris | |||
| 17. | HSK3486 | 2; HSK3486 | AUCt | = | 417 | ng.hr/ml | ALA4020405 | ng.hr.mL-1 | Canis lupus familiaris | |||
| 18. | HSK3486 | 2; HSK3486 | Cmax | = | 233 | ng/ml | ALA4020404 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | Canis lupus familiaris | ||
| 19. | HSK3486 | 2; HSK3486 | Cmax | = | 1611 | ng/ml | ALA4020402 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | Canis lupus familiaris | ||
| 20. | HSK3486 | 2; HSK3486 | t1/2 | = | 0.44 | hr | ALA4020401 | hr | Canis lupus familiaris |
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