| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA4104355 | (S)-11 | PPB | = | 99 | % | ALA4047399 | % | Mus musculus | |||
| 2. | ALA4104355 | (S)-11 | PPB | = | 99 | % | ALA4047398 | % | Rattus norvegicus | |||
| 3. | ALA4104355 | (S)-11 | PPB | = | 99 | % | ALA4047397 | % | Homo sapiens | |||
| 4. | ALA4104355 | (S)-11 | Drug uptake | = | 99 | uM | ALA4047396 | uM | ||||
| 5. | ALA4104355 | (S)-11 | Drug uptake | = | 101 | uM | ALA4047395 | uM | ||||
| 6. | ALA4104355 | (S)-11 | Cp | = | 8.21 | uM | ALA4047394 | uM | Mus musculus | |||
| 7. | ALA4104355 | (S)-11 | Cp | = | 18.9 | uM | ALA4047393 | uM | Mus musculus | |||
| 8. | ALA4104355 | (S)-11 | INH | = | 61 | % | ALA4047392 | % | Mus musculus | |||
| 9. | ALA4104355 | (S)-11 | INH | = | 60 | % | ALA4047391 | % | Mus musculus | |||
| 10. | ALA4104355 | (S)-11 | Vdss | = | 20.9 | L/Kg | ALA4047390 | L.kg-1 | Rattus norvegicus | |||
| 11. | ALA4104355 | (S)-11 | CL | = | 1.1 | L/hr/kg | ALA4047389 | mL.min-1.kg-1 | Rattus norvegicus | |||
| 12. | ALA4104355 | (S)-11 | t1/2 | = | 13.6 | hr | ALA4047388 | hr | Rattus norvegicus | |||
| 13. | ALA4104355 | (S)-11 | Cmax | = | 390 | ng/ml | ALA4047387 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | Rattus norvegicus | ||
| 14. | ALA4104355 | (S)-11 | AUC | = | 7450 | ng.hr/ml | ALA4047386 | ng.hr.mL-1 | Rattus norvegicus | |||
| 15. | ALA4104355 | (S)-11 | AUC | = | 2620 | ng.hr/ml | ALA4047385 | ng.hr.mL-1 | Rattus norvegicus | |||
| 16. | ALA4104355 | (S)-11 | IC50 | = | 21 | uM | ALA4047384 | 4.68 | nM | Homo sapiens | ||
| 17. | ALA4104355 | (S)-11 | IC50 | > | 30 | uM | ALA4047383 | nM | Homo sapiens | |||
| 18. | ALA4104355 | (S)-11 | Stability | = | 10 | % | ALA4047382 | % | Mus musculus | |||
| 19. | ALA4104355 | (S)-11 | Stability | = | 6 | % | ALA4047381 | % | Rattus norvegicus | |||
| 20. | ALA4104355 | (S)-11 | Stability | = | 1 | % | ALA4047380 | % | Homo sapiens |
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