| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  S18-000003 | 25; S18-000003 | Tmax | = | 0.8 | hr | ALA4264819 | hr | Mus musculus | |||
| 2. | S18-000003 | 25; S18-000003 | Tmax | = | 1.5 | hr | ALA4264818 | hr | Mus musculus | |||
| 3. | S18-000003 | 25; S18-000003 | Cmax | = | 17800 | ng/ml | ALA4264817 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | Mus musculus | ||
| 4. | S18-000003 | 25; S18-000003 | Cmax | = | 8350 | ng/ml | ALA4264816 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | Mus musculus | ||
| 5. | S18-000003 | 25; S18-000003 | AUC | = | 96300 | ng.hr/ml | ALA4264815 | ng.hr.mL-1 | Mus musculus | |||
| 6. | S18-000003 | 25; S18-000003 | AUC | = | 43500 | ng.hr/ml | ALA4264814 | ng.hr.mL-1 | Mus musculus | |||
| 7. | S18-000003 | 25; S18-000003 | INH | = | 63 | % | ALA4264813 | % | Mus musculus | |||
| 8. | S18-000003 | 25; S18-000003 | INH | = | 41 | % | ALA4264812 | % | Mus musculus | |||
| 9. | S18-000003 | 25; S18-000003 | INH | 0 | ALA4264811 | Dose-dependent effect | % | Mus musculus | ||||
| 10. | S18-000003 | 25; S18-000003 | Fu | = | 3.4 | % | ALA4264810 | |||||
| 11. | S18-000003 | 25; S18-000003 | F | = | 54.5 | % | ALA4264809 | % | Rattus norvegicus | |||
| 12. | S18-000003 | 25; S18-000003 | Tmax | = | 4 | hr | ALA4264808 | hr | Rattus norvegicus | |||
| 13. | S18-000003 | 25; S18-000003 | AUC | = | 2110 | ng.hr/ml | ALA4264807 | ng.hr.mL-1 | Rattus norvegicus | |||
| 14. | S18-000003 | 25; S18-000003 | Cmax | = | 185 | ng/ml | ALA4264806 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | Rattus norvegicus | ||
| 15. | S18-000003 | 25; S18-000003 | Vdss | = | 1.1 | L/Kg | ALA4264805 | L.kg-1 | Rattus norvegicus | |||
| 16. | S18-000003 | 25; S18-000003 | t1/2 | = | 3.2 | hr | ALA4264804 | hr | Rattus norvegicus | |||
| 17. | S18-000003 | 25; S18-000003 | CL | = | 4.33 | ml/min.kg | ALA4264803 | mL.min-1.kg-1 | Rattus norvegicus | |||
| 18. | S18-000003 | 25; S18-000003 | AUC | = | 1930 | ng.hr/ml | ALA4264802 | ng.hr.mL-1 | Rattus norvegicus | |||
| 19. | S18-000003 | 25; S18-000003 | EC50 | > | 30 | uM | ALA4264801 | nM | Homo sapiens | |||
| 20. | S18-000003 | 25; S18-000003 | EC50 | > | 30 | uM | ALA4264800 | nM | Homo sapiens |
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