Activities

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Activities

Activities

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#	Name	Compound Key	Action Type	Relation	Activity Value	Units	Assay ID	Assay Description	Comment	Assay	Assay Organism
1.	ALA4296682	37, BMS-791826	Activity		0		ALA1914197		Dose-dependent effect		Rattus norvegicus
2.	ALA4296682	37, BMS-791826	Activity		0		ALA1914199		Dose-dependent effect		Rattus norvegicus
3.	ALA4296682	37, BMS-791826	ED50	=	8	mg kg-1	ALA1914203			mg.kg-1	Rattus norvegicus
4.	ALA4296682	37, BMS-791826	Activity		0		ALA1914202		Active		Rattus norvegicus
5.	ALA4296682	37, BMS-791826	Ratio	=	5.2		ALA1914198
6.	ALA4296682	37, BMS-791826	Drug uptake	=	114	nM	ALA1914196			nM	Rattus norvegicus
7.	ALA4296682	37, BMS-791826	INH	=	54	%	ALA1914195			%	Rattus norvegicus
8.	ALA4296682	37, BMS-791826	INH	>	95	%	ALA1914194			%	Rattus norvegicus
9.	ALA4296682	37, BMS-791826	EC50	=	215	nM	ALA1914193	6.67		nM	Rattus norvegicus
10.	ALA4296682	37, BMS-791826	permeability		0		ALA1914192		permeable
11.	ALA4296682	37, BMS-791826	F	=	107	%	ALA1914191			%	Rattus norvegicus
12.	ALA4296682	37, BMS-791826	F	=	17	%	ALA1914190			%	Rattus norvegicus
13.	ALA4296682	37, BMS-791826	Vdss	=	0.5	L/Kg	ALA1914189			L.kg-1	Rattus norvegicus
14.	ALA4296682	37, BMS-791826	CL	=	34	ml/min.kg	ALA1914188			mL.min-1.kg-1	Rattus norvegicus
15.	ALA4296682	37, BMS-791826	t1/2	=	0.4	hr	ALA1914187			hr	Rattus norvegicus
16.	ALA4296682	37, BMS-791826	AUC	=	28122	ng.hr/ml	ALA1914186			ng.hr.mL-1	Rattus norvegicus
17.	ALA4296682	37, BMS-791826	AUC	=	904	ng.hr/ml	ALA1914185			ng.hr.mL-1	Rattus norvegicus
18.	ALA4296682	37, BMS-791826	AUC	=	526	ng.hr/ml	ALA1914184			ng.hr.mL-1	Rattus norvegicus
19.	ALA4296682	37, BMS-791826	Tmax	=	3.3	hr	ALA1914183			hr	Rattus norvegicus
20.	ALA4296682	37, BMS-791826	Tmax	=	1	hr	ALA1914182			hr	Rattus norvegicus