# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | ALA4453785 | 19 | K(p,uu,brain) | = | 0.37 | ALA4341883 | ||||||
2. | ALA4453785 | 19 | PPB | = | 90 | % | ALA4341910 | % | ||||
3. | ALA4453785 | 19 | PPB | = | 90 | % | ALA4341909 | % | ||||
4. | ALA4453785 | 19 | PPB | = | 90 | % | ALA4341908 | % | ||||
5. | ALA4453785 | 19 | Fu | = | 3 | % | ALA4341907 | |||||
6. | ALA4453785 | 19 | Fu | = | 3 | % | ALA4341906 | |||||
7. | ALA4453785 | 19 | AUC | = | 30.95 | hr.ng/ml | ALA4341905 | ng.hr.mL-1 | ||||
8. | ALA4453785 | 19 | AUC | = | 84.7 | hr.ng/ml | ALA4341904 | ng.hr.mL-1 | ||||
9. | ALA4453785 | 19 | F | = | 31 | % | ALA4341903 | % | ||||
10. | ALA4453785 | 19 | Vd | = | 1.81 | L/Kg | ALA4341902 | L.kg-1 | ||||
11. | ALA4453785 | 19 | CL | = | 4.19 | L/kg/hr | ALA4341901 | mL.min-1.kg-1 | ||||
12. | ALA4453785 | 19 | beta t1/2 | = | 0.48 | hr | ALA4341900 | hr | ||||
13. | ALA4453785 | 19 | Cmax/dose | = | 545 | ng/ml | ALA4341899 | ng/ml | ||||
14. | ALA4453785 | 19 | Cmax/dose | = | 75.1 | ng/ml | ALA4341898 | ng/ml | ||||
15. | ALA4453785 | 19 | AUC/dose | = | 238 | hr.ng/ml | ALA4341897 | hr.ng/ml | ||||
16. | ALA4453785 | 19 | AUC/dose | = | 72.9 | hr.ng/ml | ALA4341896 | hr.ng/ml | ||||
17. | ALA4453785 | 19 | Fu | = | 4.1 | % | ALA4341895 | |||||
18. | ALA4453785 | 19 | Fu | = | 3 | % | ALA4341894 | |||||
19. | ALA4453785 | 19 | Fu | = | 5.5 | % | ALA4341893 | |||||
20. | ALA4453785 | 19 | Activity | = | 30 | uM | ALA4341892 | uM | Homo sapiens |