| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA4454483 | 1a | IC50 | = | 10155 | nM | ALA4388152 | 4.99 | nM | Homo sapiens | ||
| 2. | ALA4454483 | 1a | IC50 | = | 2230 | nM | ALA4388151 | 5.65 | nM | Homo sapiens | ||
| 3. | ALA4454483 | 1a | F | = | 59.7 | % | ALA4388150 | % | ||||
| 4. | ALA4454483 | 1a | AUC | = | 1.27 | umol/l.hr | ALA4388149 | standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | ng.hr.mL-1 | |||
| 5. | ALA4454483 | 1a | Tmax | = | 0.5 | hr | ALA4388148 | hr | ||||
| 6. | ALA4454483 | 1a | Cmax | = | 0.12 | umol/L | ALA4388147 | nM | ||||
| 7. | ALA4454483 | 1a | Vdss | = | 58.9 | L/Kg | ALA4388146 | L.kg-1 | ||||
| 8. | ALA4454483 | 1a | CL | = | 4.08 | L/hr/kg | ALA4388145 | mL.min-1.kg-1 | ||||
| 9. | ALA4454483 | 1a | AUC | = | 0.72 | umol/l.hr | ALA4388144 | standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | ng.hr.mL-1 | |||
| 10. | ALA4454483 | 1a | t1/2 | = | 13 | hr | ALA4388143 | hr | ||||
| 11. | ALA4454483 | 1a | C0 | = | 1 | umol/L | ALA4388142 | umol/L | Rattus norvegicus | |||
| 12. | ALA4454483 | 1a | IC50 | = | 42.9 | nM | ALA4388141 | 7.37 | nM | Homo sapiens | ||
| 13. | ALA4454483 | 1a | Ratio | = | 1 | ALA4388138 | ||||||
| 14. | ALA4454483 | 1a | Ratio | = | 1 | ALA4388137 | ||||||
| 15. | ALA4454483 | 1a | GI50 | = | 1.82 | uM | ALA4388134 | nM | Homo sapiens | |||
| 16. | ALA4454483 | 1a | Stability | = | 0 | % | ALA4388133 | % | ||||
| 17. | ALA4454483 | 1a | Stability | = | 84.1 | % | ALA4388132 | % | ||||
| 18. | ALA4454483 | 1a | Fu | = | 2.9 | % | ALA4388131 | |||||
| 19. | ALA4454483 | 1a | Fu | = | 4.3 | % | ALA4388130 | |||||
| 20. | ALA4454483 | 1a | permeability | = | 0.34 | 10'-6 cm/s | ALA4388129 | 10'-6 cm/s |
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