| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA4458575 | 19a | ED50 | = | 0.1 | mg kg-1 | ALA4426287 | mg.kg-1 | Rattus norvegicus | |||
| 2. | ALA4458575 | 19a | EC50 | = | 19 | nM | ALA4426287 | 7.72 | nM | Rattus norvegicus | ||
| 3. | ALA4458575 | 19a | INH | 0 | ALA4426287 | Dose-dependent effect | % | Rattus norvegicus | ||||
| 4. | ALA4458575 | 19a | Ratio | = | 2.8 | ALA4426294 | ||||||
| 5. | ALA4458575 | 19a | Ratio | = | 2.7 | ALA4426292 | ||||||
| 6. | ALA4458575 | 19a | Ratio | = | 1.9 | ALA4426291 | ||||||
| 7. | ALA4458575 | 19a | Ratio | = | 1.3 | ALA4426290 | ||||||
| 8. | ALA4458575 | 19a | Activity | 0 | ALA4426289 | Active | Mus musculus | |||||
| 9. | ALA4458575 | 19a | ED50 | = | 0.05 | mg kg-1 | ALA4426288 | mg.kg-1 | Rattus norvegicus | |||
| 10. | ALA4458575 | 19a | Activity | 0 | ALA4426285 | Dose-dependent effect | Rattus norvegicus | |||||
| 11. | ALA4458575 | 19a | EC50 | = | 5 | nM | ALA4426284 | 8.30 | nM | Homo sapiens | ||
| 12. | ALA4458575 | 19a | Stability | > | 98 | % | ALA4426283 | % | ||||
| 13. | ALA4458575 | 19a | PPB | < | 99 | % | ALA4426282 | % | ||||
| 14. | ALA4458575 | 19a | logD | = | 3.94 | ALA4426281 | ||||||
| 15. | ALA4458575 | 19a | pKa | = | 8.8 | ALA4426280 | ||||||
| 16. | ALA4458575 | 19a | permeability | = | 295 | nm/s | ALA4426279 | nm/s | ||||
| 17. | ALA4458575 | 19a | solubility | = | 229 | ug ml-1 | ALA4426278 | ug.mL-1 | ||||
| 18. | ALA4458575 | 19a | solubility | > | 850 | ug ml-1 | ALA4426277 | ug.mL-1 | ||||
| 19. | ALA4458575 | 19a | IC50 | = | 22 | uM | ALA4426276 | 4.66 | nM | Homo sapiens | ||
| 20. | ALA4458575 | 19a | IC50 | > | 40 | uM | ALA4426275 | nM | Homo sapiens |
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