| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA4458913 | 1b; G755-0559 | Kdiss | = | 2.54 | 10'-3/s | ALA4308452 | 10'-3/s | Homo sapiens | |||
| 2. | ALA4458913 | 1b; G755-0559 | AUC | = | 755 | ng.hr/ml | ALA4308461 | ng.hr.mL-1 | ||||
| 3. | ALA4458913 | 1b; G755-0559 | IC50 | = | 10.2 | nM | ALA4308448 | 7.99 | nM | Homo sapiens | ||
| 4. | ALA4458913 | 1b; G755-0559 | Vdss | = | 164 | ml/kg | ALA4308462 | L.kg-1 | ||||
| 5. | ALA4458913 | 1b; G755-0559 | IC50 | = | 9280 | nM | ALA4308450 | 5.03 | nM | Homo sapiens | ||
| 6. | ALA4458913 | 1b; G755-0559 | Kd | = | 1.14 | 10'-8M | ALA4308453 | 7.94 | nM | Homo sapiens | ||
| 7. | ALA4458913 | 1b; G755-0559 | t1/2 | = | 9 | min | ALA4308470 | hr | ||||
| 8. | ALA4458913 | 1b; G755-0559 | INH | = | 99.1 | % | ALA4308447 | % | Homo sapiens | |||
| 9. | ALA4458913 | 1b; G755-0559 | IC50 | = | 262.7 | nM | ALA4308449 | 6.58 | nM | Homo sapiens | ||
| 10. | ALA4458913 | 1b; G755-0559 | Ka | = | 0.704 | 10'5/M/s | ALA4308451 | 10'5/M/s | Homo sapiens | |||
| 11. | ALA4458913 | 1b; G755-0559 | AUClast | = | 748 | ng.hr/ml | ALA4308460 | ng.hr.mL-1 | ||||
| 12. | ALA4458913 | 1b; G755-0559 | t1/2 | = | 0.65 | hr | ALA4308466 | hr | ||||
| 13. | ALA4458913 | 1b; G755-0559 | Ki | = | 67 | nM | ALA4308456 | 7.17 | nM | Homo sapiens | ||
| 14. | ALA4458913 | 1b; G755-0559 | AUC | = | 1790 | ng.hr/ml | ALA4308468 | ng.hr.mL-1 | ||||
| 15. | ALA4458913 | 1b; G755-0559 | Papp | = | 3.73 | 10'-6 cm/s | ALA4308472 | 10'-6 cm/s | ||||
| 16. | ALA4458913 | 1b; G755-0559 | CL | = | 4.43 | ml/min.kg | ALA4308463 | mL.min-1.kg-1 | ||||
| 17. | ALA4458913 | 1b; G755-0559 | F | = | 16 | % | ALA4308469 | % | ||||
| 18. | ALA4458913 | 1b; G755-0559 | Ratio Ki | = | 3 | ALA4308458 | Homo sapiens | |||||
| 19. | ALA4458913 | 1b; G755-0559 | Cmax | = | 1140 | ng/ml | ALA4308464 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | |||
| 20. | ALA4458913 | 1b; G755-0559 | IC50 | = | 33.6 | nM | ALA4308473 | 7.47 | nM | Rattus norvegicus |
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