| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA4469761 | 4c | Ratio | = | 1.9 | ALA4388275 | ||||||
| 2. | ALA4469761 | 4c | EC50 | = | 7 | uM | ALA4388231 | 5.16 | nM | Trypanosoma brucei | ||
| 3. | ALA4469761 | 4c | GI | > | 60 | % | ALA4388233 | % | Trypanosoma brucei | |||
| 4. | ALA4469761 | 4c | INH | > | 60 | % | ALA4388232 | % | Leishmania major | |||
| 5. | ALA4469761 | 4c | Ratio IC50 | = | 2 | ALA4388274 | ||||||
| 6. | ALA4469761 | 4c | Activity | 0 | ALA4388273 | Not Active | Trypanosoma brucei brucei | |||||
| 7. | ALA4469761 | 4c | CL | = | 41 | ml/min.kg | ALA4388272 | mL.min-1.kg-1 | ||||
| 8. | ALA4469761 | 4c | CL | = | 68 | ml/min.kg | ALA4388271 | mL.min-1.kg-1 | ||||
| 9. | ALA4469761 | 4c | CL | = | 946 | ml/min.kg | ALA4388270 | mL.min-1.kg-1 | ||||
| 10. | ALA4469761 | 4c | t1/2 | = | 34.8 | hr | ALA4388269 | hr | ||||
| 11. | ALA4469761 | 4c | t1/2 | = | 43.5 | hr | ALA4388268 | hr | ||||
| 12. | ALA4469761 | 4c | t1/2 | = | 3.45 | hr | ALA4388267 | hr | ||||
| 13. | ALA4469761 | 4c | AUC | = | 7932 | ng/mL.hr | ALA4388266 | ng.hr.mL-1 | ||||
| 14. | ALA4469761 | 4c | AUC | = | 4686 | ng/mL.hr | ALA4388265 | ng.hr.mL-1 | ||||
| 15. | ALA4469761 | 4c | AUC | = | 1057 | ng/mL.hr | ALA4388264 | ng.hr.mL-1 | ||||
| 16. | ALA4469761 | 4c | Cmax | = | 13 | uM | ALA4388263 | nM | ||||
| 17. | ALA4469761 | 4c | Cmax | = | 826 | ng/ml | ALA4388262 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | |||
| 18. | ALA4469761 | 4c | Cmax | = | 1630 | ng/ml | ALA4388261 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | |||
| 19. | ALA4469761 | 4c | Selectivity Index | > | 10 | ALA4388260 | ||||||
| 20. | ALA4469761 | 4c | Ratio GI50/EC50 | > | 10 | ALA4388259 |
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