| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA4470864 | 14b; JR14b | EC50 | > | 100 | uM | ALA4380983 | nM | Homo sapiens | |||
| 2. | ALA4470864 | 14b; JR14b | pIC50 | = | 8.2 | ALA4380985 | 8.20 | nM | Homo sapiens | |||
| 3. | ALA4470864 | 14b; JR14b | Activity | = | 49 | % | ALA4381003 | % | Rattus norvegicus | |||
| 4. | ALA4470864 | 14b; JR14b | CL | = | 18 | ml/min.kg | ALA4381002 | mL.min-1.kg-1 | ||||
| 5. | ALA4470864 | 14b; JR14b | beta t1/2 | = | 45 | min | ALA4381001 | hr | ||||
| 6. | ALA4470864 | 14b; JR14b | Vd | = | 0.7 | l | ALA4381000 | l | ||||
| 7. | ALA4470864 | 14b; JR14b | AUC | = | 779 | ng.hr/ml | ALA4380999 | ng.hr.mL-1 | ||||
| 8. | ALA4470864 | 14b; JR14b | Cmax | = | 23 | ng/ml | ALA4380998 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | |||
| 9. | ALA4470864 | 14b; JR14b | Tmax | = | 240 | min | ALA4380997 | hr | ||||
| 10. | ALA4470864 | 14b; JR14b | AUC | = | 90 | ng.hr/ml | ALA4380996 | ng.hr.mL-1 | ||||
| 11. | ALA4470864 | 14b; JR14b | Ratio IC50 | = | 100 | ALA4380994 | Homo sapiens | |||||
| 12. | ALA4470864 | 14b; JR14b | INH | 0 | ALA4380993 | Dose-dependent effect | % | Homo sapiens | ||||
| 13. | ALA4470864 | 14b; JR14b | pIC50 | = | 8.7 | ALA4380993 | 8.70 | nM | Homo sapiens | |||
| 14. | ALA4470864 | 14b; JR14b | IC50 | = | 2 | nM | ALA4380993 | 8.70 | nM | Homo sapiens | ||
| 15. | ALA4470864 | 14b; JR14b | Drug degradation | = | 40 | % | ALA4380992 | % | ||||
| 16. | ALA4470864 | 14b; JR14b | Stability | 0 | ALA4380989 | Stable | % | |||||
| 17. | ALA4470864 | 14b; JR14b | INH | 0 | ALA4380988 | Not Active | % | Homo sapiens | ||||
| 18. | ALA4470864 | 14b; JR14b | Ratio IC50 | = | 100 | ALA4380986 | Homo sapiens | |||||
| 19. | ALA4470864 | 14b; JR14b | pEC50 | < | 4 | ALA4380983 | nM | Homo sapiens | ||||
| 20. | ALA4470864 | 14b; JR14b | INH | 0 | ALA4380985 | Dose-dependent effect | % | Homo sapiens |
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